Cyclopropylmethanaminium chloride

Base Information

• Chemical Name: Cyclopropylmethanaminium chloride
• CAS No.: 7252-53-1
• Molecular Formula: C4H10ClN
• Molecular Weight: 107.583
• Hs Code.: 2921300090
• Mol file: 7252-53-1.mol

Synonyms:cyclopropylmethanaminium chloride;(cyclopropylmethyl)amine hydrochloride;NS00080365

Chemical Property of Cyclopropylmethanaminium chloride

Chemical Property:

• Appearance/Colour: White Powder, Crystals, Crystalline Powder, and/or Chunks
• Melting Point: 200 °C(lit.)
• Boiling Point: 86.1oC at 760 mmHg
• PSA: 26.02000
• Density: 0.912g/cm3
• LogP: 1.85740
• Sensitive.: Hygroscopic
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 107.0501770
• Heavy Atom Count: 6
• Complexity: 30.6

Purity/Quality:

99% ^*data from raw suppliers

Cyclopropanemethylamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC1C[NH3+].[Cl-]

Technology Process of Cyclopropylmethanaminium chloride

There total 4 articles about Cyclopropylmethanaminium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

cyclopropropanecarbonitrile (5500-21-0) → (aminomethyl)cyclopropane hydrochloride (7252-53-1)

Guidance literature:

cyclopropropanecarbonitrile; With cobalt pivalate; 1,1,3,3-Tetramethyldisiloxane; tert-butylisonitrile; at 80 ℃; for 24h;

With hydrogenchloride; In diethyl ether; at 20 ℃; for 0.5h;

DOI:10.1021/acs.orglett.8b03736

Reference yield: 90.0%

(nitromethyl)cyclopropane (2625-33-4) → (aminomethyl)cyclopropane hydrochloride (7252-53-1)

Guidance literature:

(nitromethyl)cyclopropane; With C₃₆H₅₆Cl₃CrN₂O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 60 ℃; for 24h; Inert atmosphere; Schlenk technique;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate; at 20 ℃;

DOI:10.1021/jacs.0c12318

Reference yield: 77.0%

Cyclopropancarbamid (6228-73-5) → (aminomethyl)cyclopropane hydrochloride (7252-53-1)

Guidance literature:

Cyclopropancarbamid; With phenylsilane; C₂₈H₁₈ClMnN₂O₂; potassium tert-butylate; In tetrahydrofuran; at 50 ℃; for 12h; Inert atmosphere; Glovebox;

With sodium hydroxide; In tetrahydrofuran; for 3h; Inert atmosphere; Glovebox;

With hydrogenchloride; In methanol; diethyl ether; Glovebox; Inert atmosphere;

DOI:10.1039/c9cc05856g

upstream raw materials:

cyclopropropanecarbonitrile

Cyclopropancarbamid

(nitromethyl)cyclopropane

Downstream raw materials:

Cyclopropylmethanol

cyclobutanol

1-(cyclopropylmethyl)urea

(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-cyclopropylmethyl-amine

Refernces

• 1、 Bhunia, Mrinal,Sahoo, Sumeet Ranjan,Das, Arpan,Ahmed, Jasimuddin,Sreejyothi,Mandal, Swadhin K.. "Transition metal-free catalytic reduction of primary amides using an abnormal NHC based potassium complex: Integrating nucleophilicity with Lewis acidic activation". . p. 1848 - 1854. Retrieved 2020/03/03.
• 2、 Das, Hari S.,Das, Shyamal,Dey, Kartick,Singh, Bhagat,Haridasan, Rahul,Das, Arpan,Ahmed, Jasimuddin,Mandal, Swadhin K.. "Primary amides to amines or nitriles: A dual role by a single catalyst". supporting information. p. 11868 - 11871. Retrieved 2019/10/11.