6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID
• CAS No.: 343-10-2
• Molecular Formula: C10H6FNO3
• Molecular Weight: 207.161
• Hs Code.: 2933499090
• Mol file: 343-10-2.mol

Synonyms:6-Fluoro-4-hydroxyquinoline-3-carboxylicacid;6-Fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid;3-Quinolinecarboxylic acid, 6-fluoro-1,4-dihydro-4-oxo-;6-Fluoro-4-hydroxy-quinoline-3-carboxylic acid;

Chemical Property of 6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID

Chemical Property:

• Boiling Point: 362.7 °C at 760 mmHg
• Flash Point: 173.2 °C
• PSA: 70.42000
• Density: 1.517 g/cm³
• LogP: 1.77770
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Fluoro-4-hydroxyquinoline-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID

There total 13 articles about 6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl 6-fluoro-4-hydroxy-3-quinoline-carboxylate (318-35-4) → 6-fluoro-4-hydroxy-quinoline-3-carboxylic acid (343-10-2)

Guidance literature:

With sodium hydroxide; water; at 1 ℃; Heating;

DOI:10.1016/S0022-1139(98)00310-8

Reference yield: 53.0%

4-fluoroaniline (371-40-4) → 6-fluoro-4-hydroxy-quinoline-3-carboxylic acid (343-10-2)

Guidance literature:

Reference yield: 53.0%

→ 6-fluoro-4-hydroxy-quinoline-3-carboxylic acid (343-10-2)

Guidance literature:

upstream raw materials:

ethyl 6-fluoro-4-hydroxy-3-quinoline-carboxylate

diethyl 2-(4-fluoroanilino)methylenemalonate

4-fluoroaniline

6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methyl ester

Downstream raw materials:

N,4-dihydroxy-6-fluoro-N-phenyl-3-quinoline carboxamide

N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxamide

4-Chloro-6-fluoroquinoline

6-Fluoro-4-hydroxyquinoline

Refernces

• 1、 -. "Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases". Paragraph 0353. . Retrieved 2015/09/22.
• 2、 -. "MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS". . . Retrieved 2012/12/14.