tert-butyl 1-(4-(2-cyclopropyl-7-phenylfuro[2,3-b]pyrazin-6-yl)phenyl)cyclobutylcarbamate

Base Information

• Chemical Name: tert-butyl 1-(4-(2-cyclopropyl-7-phenylfuro[2,3-b]pyrazin-6-yl)phenyl)cyclobutylcarbamate
• CAS No.: 1301612-88-3
• Molecular Formula: C₃₀H₃₁N₃O₃
• Molecular Weight: 481.594
• Mol file: 1301612-88-3.mol

Synonyms:tert-butyl 1-(4-(2-cyclopropyl-7-phenylfuro[2,3-b]pyrazin-6-yl)phenyl)cyclobutylcarbamate

Chemical Property of tert-butyl 1-(4-(2-cyclopropyl-7-phenylfuro[2,3-b]pyrazin-6-yl)phenyl)cyclobutylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 1-(4-(2-cyclopropyl-7-phenylfuro[2,3-b]pyrazin-6-yl)phenyl)cyclobutylcarbamate

There total 6 articles about tert-butyl 1-(4-(2-cyclopropyl-7-phenylfuro[2,3-b]pyrazin-6-yl)phenyl)cyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

potassium cyclopropyltrifluoroborate (1065010-87-8) + tert-butyl 1-(4-(2-chloro-7-phenylfuro[2,3-b]pyrazin-6-yl)phenyl)cyclobutylcarbamate (1301612-83-8) → tert-butyl 1-(4-(2-cyclopropyl-7-phenylfuro[2,3-b]pyrazin-6-yl)phenyl)cyclobutylcarbamate (1301612-88-3)

Guidance literature:

With caesium carbonate; palladium diacetate; catacxium A; In α,α,α-trifluorotoluene; water; at 120 ℃; for 1h; Sealed tube; Microwave irradiation;

Reference yield:

tert-butyl (1-(4-bromophenyl)cyclobutyl)carbamate (1032350-06-3) → tert-butyl 1-(4-(2-cyclopropyl-7-phenylfuro[2,3-b]pyrazin-6-yl)phenyl)cyclobutylcarbamate (1301612-88-3)

Guidance literature:

Multi-step reaction with 6 steps

1: diisopropylamine / copper(l) iodide; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 20 h / 20 - 80 °C / Inert atmosphere

2: potassium carbonate; methanol / 1 h

3: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

4: iodine / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

5: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

6: caesium carbonate / palladium diacetate; catacxium A / water; α,α,α-trifluorotoluene / 1 h / 120 °C / Sealed tube; Microwave irradiation

With methanol; potassium phosphate; iodine; potassium carbonate; caesium carbonate; triethylamine; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium diacetate; catacxium A; In 1,4-dioxane; dichloromethane; α,α,α-trifluorotoluene; water; N,N-dimethyl-formamide;

Reference yield:

tert-butyl 1-(4-ethynylphenyl)cyclobutylcarbamate (1301610-33-2) → tert-butyl 1-(4-(2-cyclopropyl-7-phenylfuro[2,3-b]pyrazin-6-yl)phenyl)cyclobutylcarbamate (1301612-88-3)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

2: iodine / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

3: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

4: caesium carbonate / palladium diacetate; catacxium A / water; α,α,α-trifluorotoluene / 1 h / 120 °C / Sealed tube; Microwave irradiation

With potassium phosphate; iodine; caesium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; catacxium A; In dichloromethane; α,α,α-trifluorotoluene; water; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl (1-(4-bromophenyl)cyclobutyl)carbamate

potassium cyclopropyltrifluoroborate

tert-butyl 1-(4-(2-chloro-7-phenylfuro[2,3-b]pyrazin-6-yl)phenyl)cyclobutylcarbamate

tert-butyl 1-(4-ethynylphenyl)cyclobutylcarbamate

Refernces