Potassium cyclopropyltrifluoroborate

Base Information

• Chemical Name: Potassium cyclopropyltrifluoroborate
• CAS No.: 1065010-87-8
• Molecular Formula: C3H5BF3K
• Molecular Weight: 147.977
• Hs Code.: 2931900090
• Mol file: 1065010-87-8.mol

Synonyms:PotassiuM Cyclopropyltrifluoroborate;potassium,cyclopropyl(trifluoro)boranuide;

Chemical Property of Potassium cyclopropyltrifluoroborate

Chemical Property:

• Melting Point: 348-350 °C
• PSA: 0.00000
• LogP: 1.99780
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98% ^*data from raw suppliers

Potassium Cyclopropyltrifluoroborate ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-37-60

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Organotrifluoroborate involved in Suzuki-Miyaura cross-coupling reactions1,2,3,4,5,6Organotrifluoroborates as versatile and stable boronic acid surrogates. suzuki reaction Organotrifluoroborate involved in Suzuki-Miyaura cross-coupling reactionsOrganotrifluoroborates as versatile and stable boronic acid surrogates.

Technology Process of Potassium cyclopropyltrifluoroborate

There total 1 articles about Potassium cyclopropyltrifluoroborate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

cyclopropylboronic acid (411235-57-9) → potassium cyclopropyltrifluoroborate (1065010-87-8)

Guidance literature:

With potassium hydrogenfluoride; In methanol; water;

DOI:10.1002/mrc.2467

Reference yield: 100.0%

potassium cyclopropyltrifluoroborate (1065010-87-8) + tert-butyl 1-(4-(2-chloro-7-phenylfuro[2,3-b]pyrazin-6-yl)phenyl)cyclobutylcarbamate (1301612-83-8) → tert-butyl 1-(4-(2-cyclopropyl-7-phenylfuro[2,3-b]pyrazin-6-yl)phenyl)cyclobutylcarbamate (1301612-88-3)

Guidance literature:

With caesium carbonate; palladium diacetate; catacxium A; In α,α,α-trifluorotoluene; water; at 120 ℃; for 1h; Sealed tube; Microwave irradiation;

Reference yield: 99.0%

potassium cyclopropyltrifluoroborate (1065010-87-8) + ethyl 4-({(1-bromo-4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate (1400702-26-2) → ethyl 4-({(1-cyclopropyl-4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl] amino}sulfonyl)benzoate (1400698-63-6)

Guidance literature:

With caesium carbonate; palladium diacetate; catacxium A; In water; toluene; for 3h; Inert atmosphere; Reflux;

upstream raw materials:

cyclopropylboronic acid

Downstream raw materials:

1-cyclopropyl-4-benzonitrile

5-cyclopropyl-furan-2-carbaldehyde

5-cyclopropyl-2-thiophenecarboxaldehyde

5-cyclopropyl-2-methoxypyridine

Refernces

• 1、 Lennox, Alastair J. J.,Lloyd-Jones, Guy C.. "Organotrifluoroborate hydrolysis: Boronic acid release mechanism and an acid-base paradox in cross-coupling". supporting information; experimental part. p. 7431 - 7441. Retrieved 2012/06/16.