3,4-DICHLOROBENZOIC ANHYDRIDE

Base Information

• Chemical Name: 3,4-DICHLOROBENZOIC ANHYDRIDE
• CAS No.: 86866-14-0
• Molecular Formula: C14H6 Cl4 O3
• Molecular Weight: 364.01
• Hs Code.: 2916399090
• Mol file: 86866-14-0.mol

Synonyms:Benzoicacid, 3,4-dichloro-, anhydride (9CI); 3,4-Dichlorobenzoic acid anhydride;3,4-Dichlorobenzoic anhydride

Chemical Property of 3,4-DICHLOROBENZOIC ANHYDRIDE

Chemical Property:

• Vapor Pressure: 4.32E-10mmHg at 25°C
• Melting Point: 148-150℃
• Boiling Point: 499°C at 760 mmHg
• Flash Point: 202.4°C
• PSA: 43.37000
• Density: 1.551
• LogP: 5.29740
• Sensitive.: Moisture Sensitive

Purity/Quality:

99% ^*data from raw suppliers

3,4-Dichlorobenzoic anhydride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-DICHLOROBENZOIC ANHYDRIDE

There total 4 articles about 3,4-DICHLOROBENZOIC ANHYDRIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

potassium 3,4-dichlorobenzoate + 3,4-dichlorbenzoic acid (51-44-5) → 3,4-dichlorobenzoic anhydride (86866-14-0)

Guidance literature:

3,4-dichlorbenzoic acid; With trichloroisocyanuric acid; triphenylphosphine; In dichloromethane; at 0 - 20 ℃;

potassium 3,4-dichlorobenzoate; In dichloromethane; at 20 ℃; for 1.66667h;

DOI:10.1515/chempap-2015-0042

Reference yield: 81.0%

3,4-dichlorobenzoyl chloride (3024-72-4) → 3,4-dichlorobenzoic anhydride (86866-14-0)

Guidance literature:

With water; triethylamine; In acetone; at 20 ℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201813182

Reference yield: 76.0%

3,4-dichlorbenzoic acid (51-44-5) + 3,4-dichlorobenzoyl chloride (3024-72-4) → 3,4-dichlorobenzoic anhydride (86866-14-0)

Guidance literature:

With pyridine; In diethyl ether; at 25 ℃; for 2h;

DOI:10.1021/jm00402a013

upstream raw materials:

3,4-dichlorbenzoic acid

3,4-dichlorobenzoyl chloride

Downstream raw materials:

N^α-(4-amino-4-deoxypteroyl)-N^δ-(3,4-dichlorobenzoyl)-L-ornithine

N^α-(4-amino-4-deoxy-N¹⁰-formylpteroyl)-N^δ-(3,4-dichlorobenzoyl)-L-ornithine

Refernces

• 1、 Rouhi-Saadabad, Hamed,Akhlaghinia, Batool. "Facile and direct synthesis of symmetrical acid anhydrides using a newly prepared powerful and efficient mixed reagent". . p. 479 - 485. Retrieved 2015/01/30.