Technology Process of 11-<<(benzyl)(methyl)amino>methyl>-10,11-dihydro-5H-pyrrolo<2,1-c><1,4>benzodiazepine
There total 10 articles about 11-<<(benzyl)(methyl)amino>methyl>-10,11-dihydro-5H-pyrrolo<2,1-c><1,4>benzodiazepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
platinum(IV) oxide;
In
acetic acid; ethyl acetate;
for 1.5h;
Yield given;
Ambient temperature;
DOI:10.1002/jhet.5570200626
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1. Br2 / Ambient temperature; 1. CCl4, irradiation, reflux, 4h; 2. r.t., overnight
2: 12N hydrochloric acid / ethanol / Ambient temperature; overnight
3: 86 percent / acetic acid / 0.08 h / Heating
4: 64 percent / HCl (g) / diethyl ether / 10 degC, 3h, then r.t., overnight
5: 83 percent / H2O / 1 h / 80 °C
6: 87 percent / triethylamine / toluene / 6 h / 95 °C / r.t., overnight
7: H2 / PtO2 / ethyl acetate / 3.5 h / Ambient temperature
8: H2 / PtO2 / acetic acid; ethyl acetate / 1.5 h / Ambient temperature
With
hydrogenchloride; hydrogen; bromine; triethylamine;
platinum(IV) oxide;
In
diethyl ether; ethanol; water; acetic acid; ethyl acetate; toluene;
DOI:10.1002/jhet.5570200626
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 86 percent / acetic acid / 0.08 h / Heating
2: 64 percent / HCl (g) / diethyl ether / 10 degC, 3h, then r.t., overnight
3: 83 percent / H2O / 1 h / 80 °C
4: 87 percent / triethylamine / toluene / 6 h / 95 °C / r.t., overnight
5: H2 / PtO2 / ethyl acetate / 3.5 h / Ambient temperature
6: H2 / PtO2 / acetic acid; ethyl acetate / 1.5 h / Ambient temperature
With
hydrogenchloride; hydrogen; triethylamine;
platinum(IV) oxide;
In
diethyl ether; water; acetic acid; ethyl acetate; toluene;
DOI:10.1002/jhet.5570200626