1-(2-nitrophenyl)methanamine

Base Information

• Chemical Name: 1-(2-nitrophenyl)methanamine
• CAS No.: 1904-78-5
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.153
• Hs Code.: 2921499090
• Mol file: 1904-78-5.mol

Synonyms:2-NO2C6H4CH2NH2;BEN352;o-nitrobenzylamine;2-Nitro-benzylamin;Benzenemethanamine,2-nitro;2-nitro-benzylamine;

Chemical Property of 1-(2-nitrophenyl)methanamine

Chemical Property:

• PSA: 71.84000
• LogP: 2.27700

Purity/Quality:

98%min ^*data from raw suppliers

(2-Nitrophenyl)methanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-nitrophenyl)methanamine

There total 29 articles about 1-(2-nitrophenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(2-nitrobenzyl)isoindoline-1,3-dione (35970-03-7) → 2-nitrobenzylamine (1904-78-5)

Guidance literature:

With toluene-4-sulfonic acid; hydrazine hydrate; In tetrahydrofuran; for 6h; Reflux;

DOI:10.1021/acs.orglett.7b00536

Reference yield: 87.0%

(R)-2-methyl-N-(2-nitrobenzyl)propane-2-sulfinamide (1608484-85-0) → 2-nitrobenzylamine (1904-78-5)

Guidance literature:

With water; iodine; In tetrahydrofuran; at 50 ℃;

DOI:10.1039/c4cc00958d

Reference yield: 80.0%

2-nitrobenzaldehyde oxime (3717-25-7,4836-00-4,6635-41-2) → 2-nitrobenzylamine (1904-78-5)

Guidance literature:

With sodium tetrahydroborate; amberlyst-15; lithium chloride; for 2.5h; Ambient temperature;

DOI:10.1055/s-1999-2637

upstream raw materials:

2-(2-nitrophenyl)acetic acid

2-(2-nitrobenzyl)isoindoline-1,3-dione

(2-nitro-benzylamino)-methanesulfonic acid

phenylacetonitrile

Downstream raw materials:

4-phenoxy-butyric acid-(2-nitro-benzylamide)

4-chloro-butyric acid-(2-nitro-benzylamide)

N-(2-nitro-benzyl)-β-alanine ethyl ester; hydrochloride

4-chloro-butane-1-sulfonic acid 2-nitro-benzylamide

Refernces

• 1、 Nguyen, Dat P.,Sladek, Rudolph N.,Do, Loi H.. "Scope and limitations of reductive amination catalyzed by half-sandwich iridium complexes under mild reaction conditions". supporting information. . Retrieved 2020/07/15.
• 2、 Camacho, M. Encarnación,Chayah, Mariem,García, M. Esther,Fernández-Sáez, Nerea,Arias, Fabio,Gallo, Miguel A.,Carrión, M. Dora. "Quinazolinones, Quinazolinthiones, and Quinazolinimines as Nitric Oxide Synthase Inhibitors: Synthetic Study and Biological Evaluation". . p. 638 - 650. Retrieved 2016/08/27.