Technology Process of (+)-1α-(4-(chloromethyl)phenethyl)-4-androstene-3,17-dione
There total 3 articles about (+)-1α-(4-(chloromethyl)phenethyl)-4-androstene-3,17-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-Vinylbenzyl chloride;
With
Schwartz's reagent;
In
dichloromethane;
at 20 ℃;
for 0.25h;
Inert atmosphere;
Schlenk technique;
canrenone;
With
chloro-trimethyl-silane; C36H30NO2P*Cu(1+)*CF3O3S(1-);
In
diethyl ether; dichloromethane;
at 20 ℃;
for 15h;
diastereoselective reaction;
Inert atmosphere;
Schlenk technique;
- Guidance literature:
-
4-Vinylbenzyl chloride;
With
Schwartz's reagent;
In
dichloromethane;
at 20 ℃;
for 0.25h;
Inert atmosphere;
With
C36H30CuNO2P(1+)*CF3O3S(1-);
In
diethyl ether; dichloromethane;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
Androsta-1,4-diene-3,17-dione;
With
chloro-trimethyl-silane;
In
diethyl ether; dichloromethane;
at 20 ℃;
for 15h;
Inert atmosphere;
DOI:10.1039/c2cc37155c
- Guidance literature:
-
With
C36H30NO2P*Cu(1+)*CF3O3S(1-);
In
diethyl ether; dichloromethane;
for 0.166667h;
Inert atmosphere;
With
chloro-trimethyl-silane;
In
diethyl ether; dichloromethane;
at 20 ℃;
for 15h;
With
water; ammonium chloride;
In
diethyl ether; dichloromethane;