2-Chloropyridine-4-carbonyl chloride

Base Information

• Chemical Name: 2-Chloropyridine-4-carbonyl chloride
• CAS No.: 65287-34-5
• Molecular Formula: C6H3 Cl2 N O
• Molecular Weight: 176.002
• Hs Code.: 29333990
• European Community (EC) Number: 624-963-7
• DSSTox Substance ID: DTXSID20384132
• Wikidata: Q72458458
• Mol file: 65287-34-5.mol

Synonyms:2-chloropyridine-4-carbonyl chloride;65287-34-5;2-Chloroisonicotinoylchloride;2-Chloro-isonicotinoyl chloride;2-chloroisonicotinoyl chloride;4-Pyridinecarbonyl chloride, 2-chloro-;2-Chloropyridine-4-carbonylchloride;2-chloro-4-pyridinecarbonyl chloride;SCHEMBL73194;6-chloroisonicotinoyl chloride;DTXSID20384132;2-chloroisonicotinic acid chloride;NPRZWOJTSGFSBF-UHFFFAOYSA-N;2-Chloropyridine4-carbonyl chloride;MFCD00204232;AKOS015848933;FS-5205;2-chloranylpyridine-4-carbonyl chloride;AMY202100114;2-Chloropyridine-4-carbonyl chloride, 97%;2-chloropyridine-4-carboxylic acid chloride;FT-0612020;EN300-214506;A835048;J-509027;Z1255450413

Chemical Property of 2-Chloropyridine-4-carbonyl chloride

Chemical Property:

• Vapor Pressure: 0.0228mmHg at 25°C
• Refractive Index: n20/D1.566
• Boiling Point: 144-148 ºC (10 mmHg)
• PKA: -1.84±0.10(Predicted)
• Flash Point: 104.7ºC
• PSA: 29.96000
• Density: 1.454g/cm3
• LogP: 2.11400
• Storage Temp.: Store under nitrogen
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 174.9591691
• Heavy Atom Count: 10
• Complexity: 140

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-ChloroisonicotinoylChloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34-29-14-25
• Safety Statements: 26-36/37/39-8-45-30-23

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C=C1C(=O)Cl)Cl
• Uses: 2-Chloroisonicotinoyl Chloride can be used to prepare insecticides.

Technology Process of 2-Chloropyridine-4-carbonyl chloride

There total 8 articles about 2-Chloropyridine-4-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloroisonicotinic acid, (6313-54-8) → 2-chloropyridine-4-carbonyl chloride (65287-34-5)

Guidance literature:

With thionyl chloride; at 80 ℃; for 3h;

Reference yield: 59.0%

4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine (383865-57-4) → 2-chloropyridine-4-carbonyl chloride (65287-34-5) + 2-chloro-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide (383869-82-7)

Guidance literature:

Reference yield:

2,6-dichloropyridine-4-carboxylic acid (5398-44-7) → 2-chloropyridine-4-carbonyl chloride (65287-34-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N₂H₄+H₂O / Erwaermen des Reaktionsprodukts mit wss. CuSO₄

2: benzene; PCl₅

With phosphorus pentachloride; hydrazine hydrate; benzene;

DOI:10.1002/hlca.19470300208

upstream raw materials:

2-chloroisonicotinic acid,

Isonicotinic acid N-oxide

2,6-dichloropyridine-4-carboxylic acid

4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine

Downstream raw materials:

2-chloro-4-pyridine carboxamide

2-chloro-3-(2,5-dimethoxybenzoyl)-4-pyridine carboxylic acid

1,3-dihydro-3-(2,5-dimethoxyphenyl)-4-chloro-3H-pyrido<3,4-e>furan-1-one

[2-Chloro-4-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-pyridin-3-yl]-(2,5-dimethoxy-phenyl)-methanol

Refernces

• 1、 -. "3-3 - diarylacrylate/amide compound containing triaryl phosphonium salt as well as preparation method and application thereof". Paragraph 0121. . Retrieved 2021/10/05.
• 2、 -. "AMIDE COMPOUNDS AND PREPARATION METHOD THEREFOR AND USE THEREOF". Page/Page column 30. . Retrieved 2021/04/23.