ETHYL 5-CHLOROTHIOPHENE-2-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 5-CHLOROTHIOPHENE-2-CARBOXYLATE
• CAS No.: 5751-82-6
• Molecular Formula: C7H7ClO2S
• Molecular Weight: 190.65
• Hs Code.: 29349990
• Mol file: 5751-82-6.mol

Synonyms:5-Chlorothiophene-2-carboxylicacid ethyl ester;Ethyl 5-chlorothiophene-2-carboxylate;

Chemical Property of ETHYL 5-CHLOROTHIOPHENE-2-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.018mmHg at 25°C
• Refractive Index: 1.545
• Boiling Point: 253.7 °C at 760 mmHg
• Flash Point: 107.3 °C
• Density: 1.312 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 5-Chlorothiophene-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/38:Irritating to eyes and skin.
• Hazard Codes: R36/38:Irritating to eyes and skin.
• Statements: 36/38
• Safety Statements: 26-36-37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 5-CHLOROTHIOPHENE-2-CARBOXYLATE

There total 9 articles about ETHYL 5-CHLOROTHIOPHENE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

5-bromo-2-chlorothiophene (2873-18-9) + diethyl dicarbonate (1609-47-8) → ethyl 5‐chlorothiophene‐2‐carboxylate (5751-82-6)

Guidance literature:

5-bromo-2-chlorothiophene; With magnesium; ethylene dibromide; In tetrahydrofuran; for 1.5h; sonification;

diethyl dicarbonate; With boron trifluoride diethyl etherate; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1055/s-2004-815944

Reference yield: 80.0%

5-Chlorothiophene-2-carboxylic acid (24065-33-6) + ethanol (64-17-5) → ethyl 5‐chlorothiophene‐2‐carboxylate (5751-82-6)

Guidance literature:

With sulfuric acid; at 80 ℃; for 16h;

Reference yield: 59.0%

2-acetyl-5-chlorothiophene (6310-09-4) + ethanol (64-17-5) → ethyl 5‐chlorothiophene‐2‐carboxylate (5751-82-6)

Guidance literature:

2-acetyl-5-chlorothiophene; ethanol; With pyridine; iodine; copper(II) oxide; for 24h; Reflux;

With potassium carbonate; for 8h; Reflux;

DOI:10.1246/bcsj.81.369

upstream raw materials:

5-Chlorothiophene-2-carboxylic acid

ethanol

5-chlorothiophene-2-carbonyl chloride

5-bromo-2-chlorothiophene

Downstream raw materials:

5-chlorothiophene-2-carboxamidine hydrochloride

(S)-5-(4-aminophenylthio)-4-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)-N-(2-phenylpropyl)thiophene-2-carboxamide

ethyl 5-(4-(((9H-fluoren-9-yl)methoxy)carbonylamino)phenylthio)-4-aminothiophene-2-carboxylate

ethyl 5-(4-(((9H-fluoren-9-yl)methoxy)carbonylamino)phenylthio)-4-nitrothiophene-2-carboxylate

Refernces

• 1、 Gavara, Laurent,Legru, Alice,Verdirosa, Federica,Sevaille, Laurent,Nauton, Lionel,Corsica, Giuseppina,Mercuri, Paola Sandra,Sannio, Filomena,Feller, Georges,Coulon, Rémi,De Luca, Filomena,Cerboni, Giulia,Tanfoni, Silvia,Chelini, Giulia,Galleni, Moreno,Docquier, Jean-Denis,Hernandez, Jean-Fran?ois. "4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors". supporting information. . Retrieved 2021/06/15.
• 2、 -. "NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS". Page/Page column 39. . Retrieved 2015/02/25.