5-Bromo-N,N-diethylpyridine-3-sulphonamide

Base Information

• Chemical Name: 5-Bromo-N,N-diethylpyridine-3-sulphonamide
• CAS No.: 62009-37-4
• Molecular Formula: C9H13BrN2O2S
• Molecular Weight: 293.18
• Hs Code.: 2935009090
• Mol file: 62009-37-4.mol

Synonyms:5-Bromo-N,N-diethyl-3-pyridinesulfonamide;

Chemical Property of 5-Bromo-N,N-diethylpyridine-3-sulphonamide

Chemical Property:

• Vapor Pressure: 7.22E-06mmHg at 25°C
• Refractive Index: 1.556
• Boiling Point: 376.5 °C at 760 mmHg
• Flash Point: 181.5 °C
• PSA: 58.65000
• Density: 1.485 g/cm³
• LogP: 2.95540
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

5-Bromo-N,N-diethylpyridine-3-sulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-N,N-diethylpyridine-3-sulphonamide

There total 4 articles about 5-Bromo-N,N-diethylpyridine-3-sulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Pyridine-3-sulfonyl chloride (16133-25-8) + diethylamine (109-89-7) → 5-bromo-pyridine-3-sulfonic acid diethylamide (62009-37-4)

Guidance literature:

With bromine;

Reference yield:

5-bromopyridine-3-sulphonyl chloride (65001-21-0) + diethylamine (109-89-7) → 5-bromo-pyridine-3-sulfonic acid diethylamide (62009-37-4)

Guidance literature:

In tetrahydrofuran; toluene; at 10 ℃; for 0.5h;

DOI:10.1055/s-0030-1259953

Reference yield:

3,5-dibromopyridine (625-92-3) → 5-bromo-pyridine-3-sulfonic acid diethylamide (62009-37-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 10 °C / Inert atmosphere

1.2: -10 - 10 °C

2.1: tetrahydrofuran; toluene / 0.5 h / 10 °C

With isopropylmagnesium chloride; In tetrahydrofuran; toluene;

DOI:10.1055/s-0030-1259953

upstream raw materials:

Pyridine-3-sulfonyl chloride

diethylamine

3,5-dibromopyridine

5-bromopyridine-3-sulphonyl chloride

Refernces

• 1、 Emura, Takashi,Yoshino, Hitoshi,Tachibana, Kazutaka,Shiraishi, Takuya,Honma, Akie,Mizutani, Akemi,Muraoka, Terushige. "Efficient and scalable synthesis of pyridine sulfonamides". . p. 1117 - 1120. Retrieved 2011/06/20.