625-92-3 Usage
Description
3,5-Dibromopyridine is an organic compound characterized by the presence of two bromine atoms at the 3rd and 5th positions of the pyridine ring. It is a light-yellow solid that exhibits unique chemical properties, making it a versatile building block in organic synthesis and a valuable intermediate for the production of various chemical compounds.
Uses
Used in Pharmaceutical Industry:
3,5-Dibromopyridine is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its reactivity allows for the creation of new molecules with potential therapeutic applications, contributing to the development of novel drugs.
Used in Chemical Synthesis:
3,5-Dibromopyridine is used as a starting material for the preparation of various organic compounds through different chemical reactions. For instance, it can be converted into 3-bromo-5-ethoxypyridine and further interact with ammonia and acetylating agents to produce 3-Acetylamino-5-ethoxypyridine. 3,5-Dibromopyridine can be utilized in the development of new chemical entities with specific applications.
Used in Ligand Preparation:
3,5-Dibromopyridine is used as a precursor in the preparation of ligands for catalysis. A Pd(0)-catalyzed cross-coupling reaction with 5-tributylstannyl-3,3'-bipyridine results in the formation of a ligand, which can be employed in various catalytic processes.
Used in the Synthesis of Pyridine Derivatives:
3,5-Dibromopyridine serves as a crucial building block in the synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives. These derivatives can be synthesized through Stille or Suzuki type reactions, which involve the use of 3,5-dibromopyridine as a reactant. These pyridine derivatives have potential applications in various fields, including pharmaceuticals and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 625-92-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 5 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 625-92:
(5*6)+(4*2)+(3*5)+(2*9)+(1*2)=73
73 % 10 = 3
So 625-92-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H3Br2N/c6-4-1-5(7)3-8-2-4/h1-3H
625-92-3Relevant articles and documents
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Green et al.
, p. 1177,1185,1188,1189 (1973)
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Synthesis, catalytic activity and medium fluorous recycle of fluorous analogues of PEPPSI catalysts
?im?nek, Ond?ej,Rybá?ková, Markéta,Svoboda, Martin,Kví?ala, Jaroslav
, (2020/06/22)
PEPPSI complexes are air and moisture stable Pd catalysts, which can be used conveniently in many coupling reactions. With the aim to obtain Pd catalysts recyclable by fluorous separation methods, we modified the structure of commercial PEPPSI complexes by per- or polyfluoroalkylation in various positions. The modifications included the use of a linear polyfluoroalkyl group instead of one aryl group on the NHC ligand, perfluoroalkylation of pyridine ligand, and substitution of chloride ligands on Pd for perfluoroalkanoates or perfluoropolyoxaalkanoates. Comparison of catalytic activity of commercial catalysts with the modified ones in Suzuki-Miyaura cross-coupling reactions showed that the fluorous modifications mostly resulted in the increase of catalytic activity. Moreover, polyfluoroalkylation enabled efficient medium fluorous recycle of the modified catalysts using a two phase aqueous DMF/HFE 7500 ether system.
Catalytic Deoxygenation of Amine and Pyridine N-Oxides Using Rhodium PCcarbeneP Pincer Complexes
Tinnermann, Hendrik,Sung, Simon,Cala, Beatrice A.,Gill, Hashir J.,Young, Rowan D.
, p. 797 - 803 (2020/03/13)
Rhodium PCcarbeneP pincer complexes 1-L (L = PPh3, PPh2(C6F5), PCy3) readily facilitate deoxygenation of amine and pyridine N-oxides. The resulting complexes exhibit δ2-C= O coordination of the resulting keto POP pincer ligand. These δ2-Ca? O linkages in the metalloepoxide complexes are readily reduced by isopropyl alcohol and various benzylic alcohols. Thus, efficient catalytic deoxygenation of amine and pyridine N-oxides is possible using complexes 1-L and isopropyl alcohol. This represents a pioneering example of PCcarbeneP pincer complexes being used as catalysts for catalytic deoxygenation.