2402-99-5Relevant articles and documents
Water Can Accelerate Homogeneous Gold Catalysis
Hashmi, A. Stephen K.,Rudolph, Matthias,Stein, Philipp M.
supporting information, p. 4264 - 4271 (2021/08/03)
A selection of gold-catalyzed reactions was examined in a kinetic study on the influence of water on the rate constant. Two intramolecular reactions and one intermolecular reaction, which proceed via proton transfer and/or protodeauration steps, were inve
Reaction of Pyridine-N-Oxides with Tertiary sp2-N-Nucleophiles: An Efficient Synthesis of Precursors for N-(Pyrid-2-yl)-Substituted N-Heterocyclic Carbenes
Bugaenko, Dmitry I.,Karchava, Alexander V.,Yurovskaya, Marina A.
supporting information, p. 5777 - 5782 (2020/12/01)
N-(Pyrid-2-yl)-substituted azolium and pyridinium salts, precursors for hybrid NHC-containing ligands, were obtained with excellent regioselectivity, employing a deoxygenative CH-functionalization of pyridine-N-oxides with substituted imidazoles, thiazoles, and pyridine. Unlike the traditional SNAr-based methods, this approach provides high yields for substrates bearing substituents of different electronic nature. The utility of azolium and pyridinium salts thus prepared was also highlighted by the synthesis of pyridyl-substituted imidazolyl-2-thione, benzodiazepine as well as 2-aminopyridines.
A 3, 5 - dibromo pyridine - N - oxide preparation method
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Paragraph 0038; 0039; 0040; 0041; 0042; 0043; 0044-0061, (2017/08/24)
The invention discloses a preparation method of 3,5-dibromopyridine-N-oxide. The preparation method comprises the following steps: A), an organic solvent is added to 3,5-dibromopyridine to prepare a 3,5-dibromopyridine solution which is taken as a reaction liquid I, and a hydrogen peroxide solution with certain concentration is prepared to serve as a reaction liquid II; and B), the reaction liquid I and the reaction liquid II react sufficiently in a microreactor, off-white crystals, namely, 3,5-dibromopyridine-N-oxide, are obtained after separation and purification, wherein in the step B, the temperature of the microreactor is controlled in a range from 40 DEG C to 80 DEG C, and the pressure is 0-2 MPa. The preparation method of 3,5-dibromopyridine-N-oxide has the advantages as follows: the reaction yield is high, and the raw material utilization rate is increased; the method is simple and easy to operate, the production process is safe, and the reaction speed and the temperature are easy to control; the productivity is high, a flow reactor does not have an amplification effect, and the repeatability is good; few impurities are generated, and purification is easy; and little three wastes are generated, and the preparation method is a typical green technology.