675590-28-0

Basic information

• Product Name: 3-BROMO-5-(P-TOLYL)PYRIDINE
• Synonyms: 3-BROMO-5-(P-TOLYL)PYRIDINE;3-Bromo-5-(4-methylphenyl)pyridine
• CAS NO: 675590-28-0
• Molecular Formula: C₁₂H₁₀BrN
• Molecular Weight: 248.12
• Mol File: 675590-28-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 321.1 °C at 760 mmHg
• Flash Point: 148 °C
• Appearance: /
• Density: 1.375
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-BROMO-5-(P-TOLYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-5-(P-TOLYL)PYRIDINE(675590-28-0)
• EPA Substance Registry System: 3-BROMO-5-(P-TOLYL)PYRIDINE(675590-28-0)

Safety Data

• Hazardous Substances Data: 675590-28-0(Hazardous Substances Data)

Usage

General Description

3-Bromo-5-(p-tolyl)pyridine is a chemical compound that falls in the category of organohalogen compounds, specifically aromatic bromides. Its chemical formula is C12H10BrN, indicating that it is made up of 12 carbon atoms, 10 hydrogen atoms, 1 bromine atom, and 1 nitrogen atom. As a brominated pyridine derivative with an attached phenyl ring, it is often employed in organic synthesis and can serve as an intermediate in the production of other chemical compounds. Exact properties such as physical appearance, boiling point, or potential hazards may depend on specific handling and storage conditions.

Upstream product

• 625-92-3 3,5-dibromopyridine 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 5142-75-6 tri(p-tolyl)bismuth 
• 5720-05-8 4-methylphenylboronic acid 

Relevant articles and documents

Unified Protocol for Cobalt-Catalyzed Oxidative Assembly of Two Aryl Metal Reagents Using Oxygen as an Oxidant

The first cobalt-catalyzed oxidative cross-coupling reaction of two aryl metal reagents is described. An equivalent amount of two aryl Grignard or lithium reagents, after mediation by an equivalent amount of simple ClTi(OEt)3, was facilely assembled under the catalysis of 1 mol % of CoCl2/10 mol % of DMPU using oxygen. The cross-couplings between various aryl metal reagents, especially between two structurally similar aryl Grignard reagents, proceeded smoothly and selectively and, thus, provided a highly general and efficient method for the construction of biaryl compounds.

Selective Suzuki-Miyaura monocouplings with symmetrical dibromoarenes and aryl ditriflates for the one-pot synthesis of unsymmetrical triaryls

The various parameters that would permit selective Suzuki-Miyaura monocouplings of symmetrical dihaloarenes were studied. High selectivity and efficiency can be obtained for a broad range of substrates by using operationally simple conditions and widely available reagents. The 38 different examples described provide a valuable toolbox for the rapid access to unsymmetrical triaryls, as illustrated by the preparation of diarylpyridine 8, terphenyl 9, and diarylpyrrole 10. By studying several key parameters, the factors that allow selective Suzuki-Miyaura monocoupling of symmetrical dihaloarenes have been outlined. This study serves as the basis for the efficient synthesis of unsymmetrical triaryls from symmetrical dibromoarenes and aryl ditriflates by a one-pot desymmetrizing double Suzuki-Miyaura coupling. Copyright

DIAZABICYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CNS AND OTHER DISORDERS

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