2-BENZYLPYRROLIDINE

Base Information

• Chemical Name: 2-BENZYLPYRROLIDINE
• CAS No.: 35840-91-6
• Molecular Formula: C11H15N
• Molecular Weight: 161.247
• Hs Code.: 2933990090
• Mol file: 35840-91-6.mol

Synonyms:2-Benzylpyrrolidine;2-Phenylmethyl-pyrrolidine;Pyrrolidine,2-benzyl- (6CI);(S)-2-Benzylpyrrolidine;

Chemical Property of 2-BENZYLPYRROLIDINE

Chemical Property:

• Vapor Pressure: 0.0258mmHg at 25°C
• Refractive Index: 1.537
• Boiling Point: 247.3 °C at 760 mmHg
• PKA: pK1: 10.31(+1) (25°C)
• Flash Point: 103.4 °C
• PSA: 12.03000
• Density: 0.988 g/cm³
• LogP: 2.30990
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99.0%Min ^*data from raw suppliers

2-Benzylpyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BENZYLPYRROLIDINE

There total 31 articles about 2-BENZYLPYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

α-benzyl-N-tert-butoxycarbonylpyrrolidine (144688-81-3) → 2-benzylpyrrolidine (35840-91-6)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 2h;

Reference yield: 90.0%

[1-(2-Benzyl-pyrrolidin-1-yl)-meth-(E)-ylidene]-tert-butyl-amine (89656-30-4) → 2-benzylpyrrolidine (35840-91-6)

Guidance literature:

With potassium hydroxide; In methanol; water; at 60 ℃; for 12h;

DOI:10.1021/ja00323a035

Reference yield: 83.9%

5-benzyl-3,4-dihydro-2H-pyrrole (69311-30-4) → 2-benzylpyrrolidine (35840-91-6)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; In methanol; for 10h;

upstream raw materials:

5-benzyl-3,4-dihydro-2H-pyrrole

trans-5-phenyl-4-penten-1-amine

[1-(2-Benzyl-pyrrolidin-1-yl)-meth-(E)-ylidene]-tert-butyl-amine

2,2,5,5-tetrametyl-1-aza-2,5-disilacyclopentane-1-propyl magnesium bromide

Downstream raw materials:

α-benzyl-N-tert-butoxycarbonylpyrrolidine

Refernces

• 1、 An, Feng,Maji, Biplab,Min, Elizabeth,Ofial, Armin R.,Mayr, Herbert. "Basicities and Nucleophilicities of Pyrrolidines and Imidazolidinones Used as Organocatalysts". supporting information. p. 1526 - 1547. Retrieved 2020/02/04.
• 2、 Paul, Anirudra,Seidel, Daniel. "α-Functionalization of Cyclic Secondary Amines: Lewis Acid Promoted Addition of Organometallics to Transient Imines". supporting information. p. 8778 - 8782. Retrieved 2019/06/07.