C₇H₆BrFN₂O

Base Information

• Chemical Name: C₇H₆BrFN₂O
• CAS No.: 1616667-62-9
• Molecular Formula: C₇H₆BrFN₂O
• Molecular Weight: 233.04
• Mol file: 1616667-62-9.mol

Synonyms:C₇H₆BrFN₂O

Chemical Property of C₇H₆BrFN₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₇H₆BrFN₂O

There total 2 articles about C₇H₆BrFN₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 5-bromopicolinate (29682-15-3) + methylamine (74-89-5) → C7H6BrFN2O (1616667-62-9)

Guidance literature:

methyl 5-bromopicolinate; With silver(II) fluoride; Inert atmosphere; Glovebox;

methylamine; In methanol; water; at 25 ℃; for 1.5h;

Reference yield:

methyl 5-bromopicolinate (29682-15-3) → C7H6BrFN2O (1616667-62-9)

Guidance literature:

Multi-step reaction with 2 steps

1: silver(II) fluoride / acetonitrile / 1 h / 20 °C / Inert atmosphere; Glovebox; Sealed tube

2: water / 1.5 h / 20 °C / Sealed tube

With silver(II) fluoride; In water; acetonitrile;

DOI:10.1021/ja5049303

Reference yield:

C7H6BrFN2O (1616667-62-9) → [6-amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxylic acid methylamide] (875051-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium hydroxide; potassium carbonate / dimethyl sulfoxide / 12 h / 80 °C / Inert atmosphere; Glovebox; Sealed tube

2.1: tributylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium fluoride / tetrahydrofuran; water / 0.03 h / 20 °C

2.2: 3 h / 20 °C

With potassium fluoride; ammonium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tributylphosphine; potassium carbonate; In tetrahydrofuran; water; dimethyl sulfoxide;

DOI:10.1021/ja5049303

upstream raw materials:

methyl 5-bromopicolinate

methylamine

Downstream raw materials:

6-amino-5-bromo-N-methyl-pyridine-2-carboxamide

[6-amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxylic acid methylamide]

Refernces

• 1、 Fier, Patrick S.,Hartwig, John F.. "Synthesis and late-stage functionalization of complex molecules through C-H fluorination and nucleophilic aromatic substitution". . p. 10139 - 10147. Retrieved 2014/08/05.