4-chloro-N,2-dihydroxybenzamide

Base Information

• Chemical Name: 4-chloro-N,2-dihydroxybenzamide
• CAS No.: 61799-78-8
• Molecular Formula: C7H6 Cl N O3
• Molecular Weight: 187.583
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID90381875
• Wikidata: Q82173027
• Mol file: 61799-78-8.mol

Synonyms:4-chloro-N,2-dihydroxybenzamide;61799-78-8;Benzamide,4-chloro-N,2-dihydroxy-;4-chloro-2,N-dihydroxy-benzamide;4-Chlorosalicylohydroxamic acid;SCHEMBL1841753;DTXSID90381875;4-chloro-N,2-dihydroxy-benzamide;YNWLFKLVCQDVSL-UHFFFAOYSA-N;MFCD00178744;AKOS000183829;AS-6538;CS-0262487;FT-0618227;EN300-82879;A833425;Z90126109

Chemical Property of 4-chloro-N,2-dihydroxybenzamide

Chemical Property:

• Melting Point: 195 °C
• PSA: 69.56000
• Density: 1.548g/cm³
• LogP: 1.55550
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 187.0036207
• Heavy Atom Count: 12
• Complexity: 176

Purity/Quality:

98%Min ^*data from raw suppliers

4-Chloro-N,2-dihydroxybenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)O)C(=O)NO

Technology Process of 4-chloro-N,2-dihydroxybenzamide

There total 3 articles about 4-chloro-N,2-dihydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methyl 4-chloro-2-hydroxybenzoate (22717-55-1) → 4-chloro-N,2-dihydroxybenzamide (61799-78-8)

Guidance literature:

methyl 4-chloro-2-hydroxybenzoate; With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; water; at 20 ℃; for 24h; Cooling with ice; Inert atmosphere;

With hydrogenchloride; for 0.5h; Reflux;

Reference yield:

phenyl 4-fluoro-2-hydroxybenzoate (1800-54-0) + methyl 4-chloro-2-hydroxybenzoate (22717-55-1) → 4-chloro-N,2-dihydroxybenzamide (61799-78-8) + 4-fluoro-N,2-dihydroxybenzamide (1643-78-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium methylate; In methanol;

Reference yield:

→ 4-chloro-N,2-dihydroxybenzamide (61799-78-8)

Guidance literature:

B1: Methylester, NH2OH;

upstream raw materials:

methyl 4-chloro-2-hydroxybenzoate

phenyl 4-fluoro-2-hydroxybenzoate

Downstream raw materials:

6-chloro-benzo[d]isoxazol-3-ol

3,6-dichlorobenzisoxazole

CBIO

7-chloro-2-(2-chloro-ethyl)-3-hydroxy-2,3-dihydro-benzo[e][1,3]oxazin-4-one

Refernces

• 1、 -. "Aralkylpiperidine (or piperazinecarboxylic) and its derivatives used for treating hypercalcemia schinzopherenia". Paragraph 0068; 0069. . Retrieved 2018/12/01.
• 2、 -. "Substituted benzisoxazole and benzisothiazole herbicidal agents". . . Retrieved 2008/06/13.