1643-78-3

Basic information

• Product Name: 4-Fluoro-N,2-dihydroxybenzaMide
• Synonyms: 4-Fluoro-N,2-dihydroxybenzaMide
• CAS NO: 1643-78-3
• Molecular Formula: C7H6FNO3
• Molecular Weight: 171.128
• Mol File: 1643-78-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-Fluoro-N,2-dihydroxybenzaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-N,2-dihydroxybenzaMide(1643-78-3)
• EPA Substance Registry System: 4-Fluoro-N,2-dihydroxybenzaMide(1643-78-3)

Safety Data

• Hazardous Substances Data: 1643-78-3(Hazardous Substances Data)

Usage

Description

4-Fluoro-N,2-dihydroxybenzamide is a chemical compound with the molecular formula C7H6FNO3. It is a derivative of salicylamide and is classified as a fluoroarene, a fluorobenzene, and a dihydroxybenzamide. 4-Fluoro-N,2-dihydroxybenzaMide is known for its potential use in pharmaceutical and medicinal applications due to its ability to interact with biological systems. It is also used as a building block in organic synthesis to create more complex molecules. The chemical structure of 4-Fluoro-N,2-dihydroxybenzamide contains a fluorine atom, which can influence its reactivity and properties in various chemical reactions and processes.

Uses

Used in Pharmaceutical and Medicinal Applications:
4-Fluoro-N,2-dihydroxybenzamide is used as a pharmaceutical and medicinal compound for its potential to interact with biological systems. Its unique chemical structure, including the presence of a fluorine atom, allows it to be a promising candidate for the development of new drugs and therapies.
Used in Organic Synthesis:
4-Fluoro-N,2-dihydroxybenzamide is used as a building block in organic synthesis for creating more complex molecules. Its versatile chemical properties and reactivity make it a valuable component in the synthesis of various organic compounds for research and industrial applications.

Upstream product

• 392-04-1 methyl 4-fluoro-2-hydroxybenzoate 
• 1800-54-0 phenyl 4-fluoro-2-hydroxybenzoate 
• 22717-55-1 methyl 4-chloro-2-hydroxybenzoate 
• 65-49-6 4-Aminosalicylic acid 
• 345-29-9 4-fluorosalicylic acid 
• 1737-21-9 4-fluoro-2-hydroxybenzoic acid ethyl ester 

Downstream Products

• 16209-22-6 4-Fluor-salicylhydroxamessigsaeure 

Relevant articles and documents

Discovery of highly potent SARS-CoV-2 Mpro inhibitors based on benzoisothiazolone scaffold

The COVID-19 pandemic has drastically impacted global economies and public health. Although vaccine development has been successful, it was not sufficient against more infectious mutant strains including the Delta variant indicating a need for alternative treatment strategies such as small molecular compound development. In this work, a series of SARS-CoV-2 main protease (Mpro) inhibitors were designed and tested based on the active compound from high-throughput diverse compound library screens. The most efficacious compound (16b-3) displayed potent SARS-CoV-2 Mpro inhibition with an IC50 value of 116 nM and selectivity against SARS-CoV-2 Mpro when compared to PLpro and RdRp. This new class of compounds could be used as potential leads for further optimization in anti COVID-19 drug discovery.

Chromatography-free, Mitsunobu-triggered heterocyclizations of salicylhydroxamic acids to 3-hydroxybenzisoxazoles

The Mitsunobu reaction has become one of the most powerful tools to alkylate acidic pronucleophiles. A significant caveat of Mitsunobu chemistry, however, is that the reaction mixture is often plagued with purification problems owing to the phosphine oxide and hydrazine dicarboxylate by-products. In addition to the development of more readily separable Mitsunobu reagents, the product's physicochemical properties may be exploited to facilitate purification. In this regard, we present a swift and efficient preparation of 3-hydroxybenzisoxazoles by the Mitsunobu-triggered heterocyclizations of salicylhydroxamic acids, which can be isolated by an acid–base work-up. As expected, a range of functional groups was compatible with the chemistry.

Substituted benzisoxazole and benzisothiazole herbicidal agents

There are provided substituted benzisoxazole and benzisothiazole compounds having the structural formula I STR1 Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.