3-Hydroxyazetidine hydrochloride

Base Information

• Chemical Name: 3-Hydroxyazetidine hydrochloride
• CAS No.: 18621-18-6
• Molecular Formula: C3H7NO^.HCl
• Molecular Weight: 109.556
• Hs Code.: 29339900
• European Community (EC) Number: 628-004-3
• DSSTox Substance ID: DTXSID30374721
• Mol file: 18621-18-6.mol

Synonyms:3-Hydroxyazetidine hydrochloride;18621-18-6;Azetidin-3-ol Hydrochloride;3-Hydroxyazetidine HCl;azetidin-3-ol hcl;azetidin-3-ol hydrochloride salt;MFCD02683887;3-Hydroxyazetidine, HCl;3-Azetidinol Hydrochloride;azetidin-3-ol;hydrochloride;3-Azetidinol, hydrochloride;azetidine-3-ol hydrochloride;Azetidin-3-ol (hydrochloride);3-hydroxyazetidinium chloride;3-hydroxy-1-azetidine hydrochloride;Azetidin-3-olHydrochloride;azetidin-3-ol.hydrochloride;SCHEMBL24204;azetidin-3-ol, hydrochloride;3hydroxyazetidine hydrochloride;3-hydroxy-azetidinium chloride;azetidin-3-ol monohydrochloride;azetidin-3-ol hydrogen chloride;3-hydroxy azetidine hydrochloride;3-hydroxy-azetidine hydrochloride;DTXSID30374721;UQUPQEUNHVVNKW-UHFFFAOYSA-N;3-(hydroxy)azetidine hydrochloride;BCP26315;CS-D0673;STR08693;AC-868;AKOS005259550;3-Hydroxyazetidine hydrochloride, 97%;PB18565;PS-9265;SB10062;HY-40144;SY002482;FT-0600972;H1264;EN300-65115;J-011949;J-519612;F2145-0848;Z1012638850;Azetidin-3-ol Hydrochloride pound>>3-Hydroxyazetidine HCl pound>>Azetidin-3-ol hcl

Chemical Property of 3-Hydroxyazetidine hydrochloride

Chemical Property:

• Appearance/Colour: white crystal
• Vapor Pressure: 0.464mmHg at 25°C
• Melting Point: 90-92 °C
• Boiling Point: 170.7 °C at 760 mmHg
• Flash Point: 120.4 °C
• PSA: 32.26000
• LogP: 0.08130
• Storage Temp.: Room temperature.
• Sensitive.: Hygroscopic
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• Water Solubility.: Soluble in water, DMSO, methanol.
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 109.0294416
• Heavy Atom Count: 6
• Complexity: 33.9

Purity/Quality:

99% ^*data from raw suppliers

Azetidin-3-ol, Hydrochloride Salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xi,Xn
• Hazard Codes: C,Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1C(CN1)O.Cl
• Uses: 3-Hydroxyazetidine hydrochloride is a useful intermediate in the synthesis of polypeptides. 3-Hydroxyazetidine hydrochloride is an building block used in a recent synthesis of a fluoroquinolone antibiotic and a useful intermediate in the synthesis of polypeptides.

Technology Process of 3-Hydroxyazetidine hydrochloride

There total 12 articles about 3-Hydroxyazetidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(diphenylmethyl)-3-azetidinol hydrochloride (90604-02-7) → azetion-3-ol hydrochloride (18621-18-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; water; at 20 ℃; for 4h; under 2625.21 Torr;

DOI:10.1038/ja.2006.34

Reference yield: 100.0%

N-acetyl-3-acetoxyazetidine (143329-27-5) → azetion-3-ol hydrochloride (18621-18-6)

Guidance literature:

With hydrogenchloride; In water; for 4h; Heating;

DOI:10.1021/jo9602579

Reference yield: 95.0%

N-(trityl)-3-hydroxyazetidine → azetion-3-ol hydrochloride (18621-18-6)

Guidance literature:

With hydrogenchloride; In chloroform; at 0 - 5 ℃; for 7h; Solvent;

upstream raw materials:

1-(diphenylmethyl)-3-azetidinol hydrochloride

N-acetyl-3-acetoxyazetidine

1-azabicyclo<1.1.0>butane

hydrogenchloride

Downstream raw materials:

1-(p-Toluenesulfonyl)azetidin-3-ol

3-hydroxy-1-(p-nitrobenzyloxycarbonyl)azetidine

1-(1,3-thiazolin-2-yl-)azetidin-3-ol

1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propionyl)azetidin-3-ol

Refernces

• 1、 Hayashi, Kazuhiko,Sato, Chisato,Hiki, Shinsuke,Kumagai, Toshio,Tamai, Satoshi,Abe, Takao,Nagao, Yoshimitsu. "Novel efficient synthesis of 1-azabicyclo[1.1.0]butane and its application to the synthesis of 1-(1,3-thiazolin-2-yl)azetidine-3-thiol useful for the pendant moiety of an oral 1β-methyicarbapenem antibiotic L- 084". . p. 3761 - 3764. Retrieved 1999.
• 2、 -. "Synthetic method of 3-hydroxyazetidine hydrochloride". Paragraph 0081-0085; 0088-0090; 0093-0095. . Retrieved 2020/11/05.
• 3、 -. "Method for preparing 3-hydroxyazetidine hydrochloride and tert-butyl 3-hydroxyazetidine-1-carboxylate". Paragraph 0057; 0058; 0059; 0060; 0061; 0062; 0063. . Retrieved 2017/08/30.