3-Azetidinol, 1-acetyl-, acetate (ester) (9CI)

Base Information

• Chemical Name: 3-Azetidinol, 1-acetyl-, acetate (ester) (9CI)
• CAS No.: 143329-27-5
• Molecular Formula: C7H11 N O3
• Molecular Weight: 157.169
• Hs Code.: 2933990090
• Mol file: 143329-27-5.mol

Synonyms:3-Azetidinol,1-acetyl-, acetate (ester) (9CI); 1-Acetyl-3-acetoxyazetidine

Chemical Property of 3-Azetidinol, 1-acetyl-, acetate (ester) (9CI)

Chemical Property:

• PSA: 46.61000
• LogP: -0.28190
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Acetoxy-1-acetylazetidine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Azetidinol, 1-acetyl-, acetate (ester) (9CI)

There total 2 articles about 3-Azetidinol, 1-acetyl-, acetate (ester) (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-tert-butyl-3-hydroxyazetidine (13156-04-2) + acetic anhydride (108-24-7) → N-acetyl-3-acetoxyazetidine (143329-27-5)

Guidance literature:

With boron trifluoride diethyl etherate; at 115 ℃;

DOI:10.1021/jo9602579

Reference yield: 41.0%

1-(diphenylmethyl)-3-hydroxyazetidine (18621-17-5) + acetic anhydride (108-24-7) → N-acetyl-3-acetoxyazetidine (143329-27-5)

Guidance literature:

With boron trifluoride diethyl etherate; at 120 ℃; for 96h;

DOI:10.1021/jo991525g

Reference yield: 100.0%

N-acetyl-3-acetoxyazetidine (143329-27-5) → azetion-3-ol hydrochloride (18621-18-6)

Guidance literature:

With hydrogenchloride; In water; for 4h; Heating;

DOI:10.1021/jo9602579

upstream raw materials:

N-tert-butyl-3-hydroxyazetidine

acetic anhydride

1-(diphenylmethyl)-3-hydroxyazetidine

Downstream raw materials:

azetion-3-ol hydrochloride

1-(3-hydroxyazetidin-1-yl)ethanone

N-acetylazetidin-3-one

Refernces

• 1、 Dave, Paritosh R.,Duddu, Rajagopal,Li, Jianchang,Surapaneni, Rao,Gilardi, Richard. "Photodimerization of N-acetyl-2-azetine: Synthesis of syn- diazatricyclooctane and anti-diazatricyclooctane (diaza-3-ladderane)". . p. 5481 - 5484. Retrieved 2007/10/03.