C₁₄H₁₄O₃

Base Information

• Chemical Name: C₁₄H₁₄O₃
• CAS No.: 1333376-25-2
• Molecular Formula: C₁₄H₁₄O₃
• Molecular Weight: 230.263
• Mol file: 1333376-25-2.mol

Synonyms:C₁₄H₁₄O₃

Chemical Property of C₁₄H₁₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₄O₃

There total 3 articles about C₁₄H₁₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-bromofuran-2-carboxylic acid methyl ester (58235-80-6) + 2,5-dimethylphenyl boronic acid (85199-06-0) → C14H14O3 (1333376-25-2)

Guidance literature:

With potassium phosphate; palladium diacetate; tricyclohexylphosphine; In water; toluene; at 100 ℃; for 12h;

DOI:10.1016/j.bmcl.2011.06.132

Reference yield:

4-bromofuran-2-carboxylic acid (3439-02-9) → C14H14O3 (1333376-25-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 12 h / Reflux

2: potassium phosphate; palladium diacetate; tricyclohexylphosphine / water; toluene / 12 h / 100 °C

With potassium phosphate; sulfuric acid; palladium diacetate; tricyclohexylphosphine; In water; toluene; 2: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.06.132

Reference yield:

4,5-dibromo-2-furoic acid (2434-03-9) → C14H14O3 (1333376-25-2)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium hydroxide; zinc / water / 3 h / 20 °C

2: sulfuric acid / 12 h / Reflux

3: potassium phosphate; palladium diacetate; tricyclohexylphosphine / water; toluene / 12 h / 100 °C

With ammonium hydroxide; potassium phosphate; sulfuric acid; palladium diacetate; zinc; tricyclohexylphosphine; In water; toluene; 3: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.06.132

upstream raw materials:

4-bromofuran-2-carboxylic acid

4,5-dibromo-2-furoic acid

4-bromofuran-2-carboxylic acid methyl ester

2,5-dimethylphenyl boronic acid

Downstream raw materials:

C₂₁H₂₁NO₂

Refernces