5-(2-Pyridyl)-1,3-oxazole

Base Information

• Chemical Name: 5-(2-Pyridyl)-1,3-oxazole
• CAS No.: 70380-73-3
• Molecular Formula: C8H6N2O
• Molecular Weight: 146.148
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID10353190
• Nikkaji Number: J2.315.047F
• Wikidata: Q82130659
• Mol file: 70380-73-3.mol

Synonyms:5-(2-pyridyl)-1,3-oxazole;70380-73-3;5-(Pyridin-2-yl)oxazole;2-(1,3-oxazol-5-yl)pyridine;5-pyridin-2-yl-1,3-oxazole;5-(Pyrid-2-yl)1,3-oxazole;2-oxazol-5-yl-pyridine;5-(2-pyridyl)oxazole;5-(Pyridin-2-yl)-1,3-oxazole;Pyridine,2-(5-oxazolyl)-;2-(5-oxazolyl)pyridine;2-(oxazol-5-yl)pyridine;SCHEMBL709051;DTXSID10353190;LUMKXMDGONYZHO-UHFFFAOYSA-N;VCA38073;MFCD00085160;AKOS023093504;PS-4620;CS-0208019;FT-0619602

Chemical Property of 5-(2-Pyridyl)-1,3-oxazole

Chemical Property:

• Vapor Pressure: 0.00692mmHg at 25°C
• Refractive Index: 1.547
• Boiling Point: 279.1 °C at 760 mmHg
• Flash Point: 129.7 °C
• PSA: 38.92000
• Density: 1.179 g/cm³
• LogP: 1.73660
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 146.048012819
• Heavy Atom Count: 11
• Complexity: 129

Purity/Quality:

98%Min ^*data from raw suppliers

5-(Pyridin-2-yl)-1,3-oxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C2=CN=CO2

Technology Process of 5-(2-Pyridyl)-1,3-oxazole

There total 6 articles about 5-(2-Pyridyl)-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

pyridine-2-carbaldehyde (1121-60-4) + [(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) → 2-(1,3-oxazol-5-yl)pyridine (70380-73-3)

Guidance literature:

With potassium carbonate; In methanol; at 65 ℃; for 4h; Inert atmosphere; Reflux;

DOI:10.1055/s-0034-1379549

Reference yield: 97.0%

pyridine-2-carbaldehyde (1121-60-4) + 1-isocyanatomethanesulfonyl-4-methyl-benzene (10564-55-3) → 2-(1,3-oxazol-5-yl)pyridine (70380-73-3)

Guidance literature:

With potassium carbonate; In methanol; for 2h; Heating;

DOI:10.1021/jm061414r

Reference yield: 71.0%

2-Hydroxymethylpyridine (586-98-1) + [(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) → 2-(1,3-oxazol-5-yl)pyridine (70380-73-3)

Guidance literature:

2-Hydroxymethylpyridine; [(p-methylphenyl)sulfonylmethyl]isonitrile; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In dimethyl sulfoxide; ethyl acetate; at 0 ℃; for 1.5h; Inert atmosphere;

With potassium hydroxide; In ethanol; water; at 0 ℃; for 0.0833333h;

DOI:10.1055/s-0035-1561391

upstream raw materials:

pyridine-2-carbaldehyde

[(p-methylphenyl)sulfonylmethyl]isonitrile

1-isocyanatomethanesulfonyl-4-methyl-benzene

2-bromo-pyridine

Downstream raw materials:

OL-135

tert-butyl 4-(3-oxo-3-(5-(pyridin-2-yl)oxazol-2-yl)propyl)phenyl(phenyl)carbamate

Refernces

• 1、 Rizeq, Natalia,Georgiades, Savvas N. "Investigation of ‘head-to-tail’-connected oligoaryl n,o-ligands as recognition motifs for cancer-relevant G-quadruplexes". . . Retrieved 2018/01/12.
• 2、 Rizeq, Natalia,Georgiades, Savvas N.. "Linear and Branched Pyridyl-Oxazole Oligomers: Synthesis and Circular Dichroism Detectable Effect on c-Myc G-Quadruplex Helicity". . p. 122 - 131. Retrieved 2016/01/26.