METHYL 2-[(2,6-DICHLORO-4-PYRIDYL)CARBONYL]-3-(METHYLAMINO)BUT-2-ENOATE

Base Information

• Chemical Name: METHYL 2-[(2,6-DICHLORO-4-PYRIDYL)CARBONYL]-3-(METHYLAMINO)BUT-2-ENOATE
• CAS No.: 82140-55-4
• Molecular Formula: C₁₂H₁₂Cl₂N₂O₃
• Molecular Weight: 303.145
• Hs Code.: 2933399090
• Mol file: 82140-55-4.mol

Synonyms:4-Pyridinepropanoicacid,2,6-dichloro-a-[1-(methylamino)ethylidene]-b-oxo-,methyl ester;methyl 2-[(2,6-dichloro-4-pyridyl)carbonyl]-3-(methylamino)but-2-enoate;

Chemical Property of METHYL 2-[(2,6-DICHLORO-4-PYRIDYL)CARBONYL]-3-(METHYLAMINO)BUT-2-ENOATE

Chemical Property:

• Vapor Pressure: 9.48E-09mmHg at 25°C
• Melting Point: 112oC
• Boiling Point: 462.9oC at 760 mmHg
• Flash Point: 233.8oC
• PSA: 68.29000
• Density: 1.34g/cm3
• LogP: 2.62840

Purity/Quality:

99% ^*data from raw suppliers

Methyl 2-[(2,6-dichloro-4-pyridyl)carbonyl]-3-(methylamino)but-2-enoate ^*data from reagent suppliers

Safty Information:

• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-[(2,6-DICHLORO-4-PYRIDYL)CARBONYL]-3-(METHYLAMINO)BUT-2-ENOATE

There total 2 articles about METHYL 2-[(2,6-DICHLORO-4-PYRIDYL)CARBONYL]-3-(METHYLAMINO)BUT-2-ENOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

β-N-Methylaminocrotonic acid methyl ester (21759-69-3) + 2,6-dichloroisonicotinoyl chloride (42521-08-4) → (E)-2-(2,6-Dichloro-pyridine-4-carbonyl)-3-methylamino-but-2-enoic acid methyl ester (82140-55-4)

Guidance literature:

With triethylamine; In toluene; at 25 ℃; for 12h;

DOI:10.1055/s-1982-29797

Reference yield:

acetoacetic acid methyl ester (105-45-3) → (E)-2-(2,6-Dichloro-pyridine-4-carbonyl)-3-methylamino-but-2-enoic acid methyl ester (82140-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / H₂O / 12 h / 20 °C

2: 76 percent / triethylamin / toluene / 12 h / 25 °C

With triethylamine; In water; toluene;

DOI:10.1055/s-1982-29797

upstream raw materials:

β-N-Methylaminocrotonic acid methyl ester

2,6-dichloroisonicotinoyl chloride

acetoacetic acid methyl ester

Refernces