2-Bromo-2-methylbutyric acid

Base Information

• Chemical Name: 2-Bromo-2-methylbutyric acid
• CAS No.: 41242-50-6
• Molecular Formula: C₅H₉BrO₂
• Molecular Weight: 181.029
• Mol file: 41242-50-6.mol

Synonyms:Butyricacid, 2-bromo-2-methyl- (6CI);2-Bromo-2-methylbutyric acid;butanoic acid, 2-bromo-2-methyl-;

Chemical Property of 2-Bromo-2-methylbutyric acid

Chemical Property:

• Vapor Pressure: 0.036mmHg at 25°C
• Refractive Index: 1.492
• Boiling Point: 223.412 °C at 760 mmHg
• Flash Point: 88.917 °C
• PSA: 37.30000
• Density: 1.522 g/cm³
• LogP: 1.63460
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

2-Bromo-2-methylbutanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Bromo-2-methylbutyric acid

There total 2 articles about 2-Bromo-2-methylbutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methylbutanoic acid (116-53-0,600-07-7) → 2-bromo-2-methyl-butyric acid (95338-79-7,41242-50-6,54267-64-0,54267-65-1)

Guidance literature:

With phosphorus; bromine; Erhitzen des Reaktionsprodukts mit Wasser;

Reference yield:

3-methylbutyric acid (503-74-2) → 2-bromo-2-methyl-butyric acid (95338-79-7,41242-50-6,54267-64-0,54267-65-1)

Guidance literature:

With bromine; at 150 - 160 ℃; im geschlossenen Rohr;

Reference yield: 62.9%

2-bromo-2-methyl-butyric acid (95338-79-7,41242-50-6,54267-64-0,54267-65-1) + 2-methoxy-phenol (90-05-1) → 2-(2-Methoxy-phenoxy)-2-methyl-butyric acid (80784-31-2)

Guidance literature:

With sodium hydroxide; for 12h; Heating;

DOI:10.1007/BF00758669

upstream raw materials:

3-methylbutyric acid

2-Methylbutanoic acid

Downstream raw materials:

2-(2-Methoxy-phenoxy)-2-methyl-butyric acid

2-((3,5-di-tert-butyl-4-hydroxyphenyl)thio)-2-methyl-butyric acid

2-hydroxy-2-methylbutyric acid

hydrogen bromide

Refernces

• 1、 Cilibrizzi, Agostino,Schepetkin, Igor A.,Bartolucci, Gianluca,Crocetti, Letizia,Dal Piaz, Vittorio,Giovannoni, Maria Paola,Graziano, Alessia,Kirpotina, Liliya N.,Quinn, Mark T.,Vergelli, Claudia. "Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists". body text. p. 3781 - 3792. Retrieved 2012/08/28.
• 2、 Johansson, Lars,Fotsch, Christopher,Bartberger, Michael D.,Castro, Victor M.,Chen, Michelle,Emery, Maurice,Gustafsson, Sonja,Hale, Clarence,Hickman, Dean,Homan, Evert,Jordan, Steven R.,Komorowski, Renee,Li, Aiwen,McRae, Kenneth,Moniz, George,Matsumoto, Guy,Orihuela, Carlos,Palm, Gunnar,Veniant, Murielle,Wang, Minghan,Williams, Meredith,Zhang, Jiandong. "2-Amino-1,3-thiazol-4(5H)-ones as potent and selective 11β- hydroxysteroid dehydrogenase type 1 inhibitors: Enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice". experimental part. p. 2933 - 2943. Retrieved 2009/04/10.