Technology Process of C22H26F3NO3
There total 4 articles about C22H26F3NO3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-bromo-2,4,5-trifluorobenzene;
With
copper(I) bromide dimethylsulfide complex; tert-butylmagnesium bromide;
In
tetrahydrofuran;
at -20 - -5 ℃;
for 0.25h;
Inert atmosphere;
C16H23NO3;
In
tetrahydrofuran;
for 0.0833333h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / Inert atmosphere
2.1: tert-butylmagnesium bromide; copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.25 h / -20 - -5 °C / Inert atmosphere
2.2: 0.08 h
With
copper(I) bromide dimethylsulfide complex; tert-butylmagnesium bromide; sodium hydride;
In
tetrahydrofuran; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / Inert atmosphere
3.1: tert-butylmagnesium bromide; copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.25 h / -20 - -5 °C / Inert atmosphere
3.2: 0.08 h
With
copper(I) bromide dimethylsulfide complex; tert-butylmagnesium bromide; sodium hydride; triethylamine;
In
tetrahydrofuran; dichloromethane; mineral oil;