6,7-Dihydro-5H-cyclopenta[b]pyridin-7-ol

Base Information

• Chemical Name: 6,7-Dihydro-5H-cyclopenta[b]pyridin-7-ol
• CAS No.: 41598-71-4
• Molecular Formula: C8H9NO
• Molecular Weight: 135.16
• Hs Code.: 2933990090
• European Community (EC) Number: 879-212-8
• DSSTox Substance ID: DTXSID50541938
• Nikkaji Number: J2.313.059I
• Mol file: 41598-71-4.mol

Synonyms:6,7-Dihydro-5H-cyclopenta[b]pyridin-7-ol;41598-71-4;MFCD07778342;5H-Cyclopenta[b]pyridin-7-ol, 6,7-dihydro-;5H,6H,7H-cyclopenta[b]pyridin-7-ol;6,7-Dihydro-5H-cyclopenta[b]pyridine-7-ol;SCHEMBL3314142;DTXSID50541938;XLPDFBUFTAWCIB-UHFFFAOYSA-N;AM9568;AKOS015919620;CS-W003424;DS-15131;SY017306;EN300-173190;A873034;6 pound not7-Dihydro-5H-cyclopenta[b]pyridin-7-ol;6,7-Dihydro-5H-cyclopenta[b]pyridin-7-ol, AldrichCPR;4-Isoxazolecarboxylic acid, 3-(4-chlorophenyl)-5-methyl-

Chemical Property of 6,7-Dihydro-5H-cyclopenta[b]pyridin-7-ol

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.618
• Boiling Point: 291.151 °C at 760 mmHg
• Flash Point: 129.884 °C
• PSA: 33.12000
• Density: 1.243 g/cm³
• LogP: 1.06120
• Storage Temp.: 2-8°C
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 135.068413911
• Heavy Atom Count: 10
• Complexity: 126

Purity/Quality:

98% ^*data from raw suppliers

6,7-Dihydro-5H-cyclopenta[b]pyridin-7-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=C(C1O)N=CC=C2

Technology Process of 6,7-Dihydro-5H-cyclopenta[b]pyridin-7-ol

There total 6 articles about 6,7-Dihydro-5H-cyclopenta[b]pyridin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate (90685-59-9) → 7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridine (41598-71-4)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 1h;

DOI:10.1055/s-0032-1318492

Reference yield:

6,7-dihydro-5H-cyclopenta[b]pyridine 1-oxide (90685-58-8) → 7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridine (41598-71-4)

Guidance literature:

6,7-dihydro-5H-cyclopenta[b]pyridine 1-oxide; With trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃; for 16h;

With lithium hydroxide; In dichloromethane; water; at 20 ℃; for 16h;

DOI:10.1021/ol060443t

Reference yield:

2,3-cyclopentenopyridine (533-37-9) → 7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridine (41598-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: mCPBA / CH₂Cl₂ / 16 h / 20 °C

2.1: trifluoroacetic anhydride / CH₂Cl₂ / 16 h / 0 - 20 °C

2.2: lithium hydroxide / CH₂Cl₂; H₂O / 16 h / 20 °C

With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In dichloromethane;

DOI:10.1021/ol060443t

upstream raw materials:

6,7-dihydro-5H-cyclopenta[b]pyridine 1-oxide

2,3-cyclopentenopyridine

6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate

5H,6H,7H-cyclopenta[b]pyridin-7-one

Downstream raw materials:

5H-1-pyrindine

7-benzoylthio-6,7-dihydro-5H-cyclopentapyridine

7-mercapto-6,7-dihydro-5H-cyclopentapyridine

5H,6H,7H-cyclopenta[b]pyridin-7-one

Refernces

• 1、 -. "SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE". . . Retrieved 2020/12/11.
• 2、 Pereira, Cidáliasilva,Salgado, Sofia,Rizzo-Aguiar, Fabio,Garcia-Mera, Xerardo,Rodríguez-Borges, Josée.. "Synthesis of New Propargylated 1-Pyrindane Derivatives as Rasagiline Analogues". . p. 837 - 838. Retrieved 2013/05/21.