N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine

Base Information Edit

Chemical Name:N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine
CAS No.:224779-27-5
Molecular Formula:C10H17 N O3
Molecular Weight:199.25
Hs Code.:2933399090
European Community (EC) Number:640-896-6
DSSTox Substance ID:DTXSID70590281
Nikkaji Number:J1.886.376F
Mol file:224779-27-5.mol

Synonyms:224779-27-5;N-BOC-3-HYDROXY-1,2,3,6-TETRAHYDROPYRIDINE;tert-Butyl 5-hydroxy-5,6-dihydropyridine-1(2H)-carboxylate;tert-butyl 3-hydroxy-1,2,3,6-tetrahydropyridine-1-carboxylate;tert-butyl 3-hydroxy-3,6-dihydro-2H-pyridine-1-carboxylate;3-hydroxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester;3-Hydroxy-1,2,3,6-tetrahydropyridine, N-BOC protected;MFCD04972246;tert-butyl 3-hydroxy-3,6-dihydropyridine-1(2H)-carboxylate;MFCD26516244;1-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine;tert-Butyl 5,6-dihydro-5-hydroxypyridine-1(2H)-carboxylate;SCHEMBL1486976;DTXSID70590281;NICJOYHYEDFTIX-UHFFFAOYSA-N;AMY24096;MFCD26516245;AKOS006343253;PS-3873;SB23140;SY011915;SY344450;SY344451;DB-007744;CS-0048293;(R)-1-Boc-1,2,3,6-tetrahydropyridin-3-ol;(S)-1-Boc-1,2,3,6-tetrahydropyridin-3-ol;EN300-190739;N-BOC-3-hydroxyl-1,2,3,6-tetrahydropyridine;P15358;A816220;W-206763;N-tert-Butoxycarbonyl-5-hydroxy-1,2,5,6-tetrahydropyridine;tert-Butyl5-hydroxy-5,6-dihydropyridine-1(2H)-carboxylate;3,6-DIHYDRO-3-HYDROXY-1(2H)-PYRIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Suppliers and Price of N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine
250mg
$ 368.00

TRC
tert-Butyl3-Hydroxy-3,6-dihydropyridine-1(2H)-carboxylate
50mg
$ 105.00

SynQuest Laboratories
3-Hydroxy-1,2,3,6-tetrahydropyridine, N-Boc protected
500 mg
$ 224.00

SynQuest Laboratories
3-Hydroxy-1,2,3,6-tetrahydropyridine, N-Boc protected
1 g
$ 360.00

SynQuest Laboratories
3-Hydroxy-1,2,3,6-tetrahydropyridine, N-Boc protected
5 g
$ 960.00

J&W Pharmlab
3-Hydroxy-3,6-dihydro-2H-pyridine-1-carboxylicacidtert-butylester 97%
25g
$ 2640.00

Crysdot
tert-Butyl5-hydroxy-5,6-dihydropyridine-1(2H)-carboxylate 95+%
5g
$ 951.00

Chemenu
N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine 95%
1g
$ 200.00

Biosynth Carbosynth
N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine
500 mg
$ 225.00

Biosynth Carbosynth
N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine
1 g
$ 300.00

Total 25 raw suppliers

Chemical Property of N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine Edit

Chemical Property:

Vapor Pressure:0.000153mmHg at 25°C
Melting Point:55-56 °C(Solv: hexane (110-54-3))
Boiling Point:295.9°Cat760mmHg
PKA:14.17±0.20(Predicted)
Flash Point:132.8°C
PSA：49.77000
Density:1.138g/cm³
LogP:1.09210
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:199.12084340
Heavy Atom Count:14
Complexity:242

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CC=CC(C1)O
Uses 1-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine is used as pharmaceutical intermediate.

Technology Process of N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine

There total 1 articles about N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85838-94-4
N-Boc-1,2,3,6-tetrahydropyridine

: 224779-27-5
tert-butyl 3-hydroxy-1,2,3,6-tetrahydropyridine-N-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 14 h / 0 - 20 °C

2: trimethylsilyl iodide / N,N-dimethyl-formamide / 20 °C / Cooling with ice

3: pyridinium p-toluenesulfonate / dichloromethane / 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / 27 h / 80 °C

5: hydrogenchloride / dichloromethane; ethyl acetate; methanol / 0 - 20 °C

With hydrogenchloride; trimethylsilyl iodide; pyridinium p-toluenesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;