Iodopyrazine

Base Information

• Chemical Name: Iodopyrazine
• CAS No.: 32111-21-0
• Molecular Formula: C4H3 I N2
• Molecular Weight: 205.986
• Hs Code.: 2933990090
• Mol file: 32111-21-0.mol

Synonyms:Pyrazine,iodo- (6CI,9CI); 2-Iodopyrazine; 3-Iodopyrazine; Iodopyrazine

Chemical Property of Iodopyrazine

Chemical Property:

• Vapor Pressure: 0.118mmHg at 25°C
• Melting Point: 90 °C (decomp)
• Refractive Index: n20/D 1.655(lit.)
• Boiling Point: 109-110 ºC (34 mmHg)
• PKA: -0.85±0.10(Predicted)
• Flash Point: 110 ºC
• PSA: 25.78000
• Density: 2.086
• LogP: 1.08120
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Light Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Iodopyrazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Iodopyrazine

There total 7 articles about Iodopyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-Aminopyrazine (5049-61-6) → 2-iodopyrazine (32111-21-0)

Guidance literature:

With N-iodo-succinimide; sodium nitrite; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1002/chem.201803347

Reference yield: 80.0%

2-chloropyrazin (14508-49-7) → 2-iodopyrazine (32111-21-0)

Guidance literature:

With sulfuric acid; acetic acid; sodium iodide; In acetonitrile; for 5h; Heating;

DOI:10.1016/S0040-4020(98)00526-2

Reference yield: 71.0%

1,4-pyrazine (290-37-9) → 2-iodopyrazine (32111-21-0)

Guidance literature:

1,4-pyrazine; With bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex; zinc(II) chloride; In tetrahydrofuran; at 25 ℃; for 0.5h; Inert atmosphere;

With iodine; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.jorganchem.2009.12.016

upstream raw materials:

1,4-pyrazine

2-chloropyrazin

hydrogen iodide

2-Aminopyrazine

Downstream raw materials:

(1R,3S,4S)-3-Pyrazin-2-yl-1-aza-bicyclo[2.2.1]heptan-3-ol

exo-3-(1,4-diazin-2-yl)-3-hydroxy-1-azabicyclo<2.2.1>heptane

2-iodo-3-formylpyrazine

(3-iodo-2-pyrazine)carboxylic acid

Refernces

• 1、 Uzelac, Marina,Kennedy, Alan R.,Hevia, Eva,Mulvey, Robert E.. "Transforming LiTMP Lithiation of Challenging Diazines through Gallium Alkyl Trans-Metal-Trapping". . p. 13147 - 13150. Retrieved 2016/10/30.
• 2、 -. "METHODS FOR SYNTHESIZING ANTIVIRAL COMPOUNDS". Page/Page column 15. . Retrieved 2009/10/22.