9H-Fluorene-9-methanamine

Base Information

• Chemical Name: 9H-Fluorene-9-methanamine
• CAS No.: 34577-90-7
• Molecular Formula: C₁₄H₁₃N
• Molecular Weight: 195.264
• Hs Code.: 2921499090
• ChEMBL ID: CHEMBL415906
• DSSTox Substance ID: DTXSID401312446
• Nikkaji Number: J1.508.651C
• Mol file: 34577-90-7.mol

Synonyms:9H-Fluorene-9-methanamine;34577-90-7;(9H-Fluoren-9-yl)methanamine;9H-fluoren-9-ylmethanamine;CHEMBL415906;C-(9H-Fluoren-9-yl)-methylamine;9-fluorenemethyl amine;9H-fluoren-9-ylmethylamine;SCHEMBL1402081;WFALOHNPWGVANH-UHFFFAOYSA-N;DTXSID401312446;BDBM50097223;AKOS006294904;1-(9H-FLUOREN-9-YL)METHANAMINE;CS-0451449;EN300-2006241;A874938

Chemical Property of 9H-Fluorene-9-methanamine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 99-100 °C
• Refractive Index: 1.636
• Boiling Point: 349.875 °C at 760 mmHg
• Flash Point: 173.581 °C
• PSA: 26.02000
• Density: 1.128 g/cm³
• LogP: 3.45790
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 195.104799419
• Heavy Atom Count: 15
• Complexity: 203

Purity/Quality:

98%min ^*data from raw suppliers

Fluoren-9-yl-methylamine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)CN

Technology Process of 9H-Fluorene-9-methanamine

There total 6 articles about 9H-Fluorene-9-methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

9H-fluorene-9-carbonitrile (1529-40-4) → 9H-fluoren-9-ylmethanamine (34577-90-7)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 50 ℃; for 0.333333h;

DOI:10.1021/jm010146o

Reference yield:

9H-fluorene-9-carboxamide (7471-95-6) → 9H-fluoren-9-ylmethanamine (34577-90-7)

Guidance literature:

With sodium trifluoroacetoxy borohydride; In 1,4-dioxane; at 60 ℃; for 5h; Yield given;

DOI:10.1039/c39810000491

Reference yield:

9-fluorenone (486-25-9,952573-42-1) → 9H-fluoren-9-ylmethanamine (34577-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / t-BuOK / CH₂Cl₂; ethanol / 1.5 h / 20 °C

2: 50 percent / BH₃*DMS / tetrahydrofuran / 0.33 h / 50 °C

With dimethylsulfide borane complex; potassium tert-butylate; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm010146o

upstream raw materials:

9H-fluorene-9-carboxamide

2-(9H-Fluoren-9-ylmethyl)-1,1,1,3,3,3-hexamethyl-disilazane

9H-fluorene-9-carbonitrile

9-fluorenone

Refernces

• 1、 -. "Anti-viral method". . . Retrieved 2008/06/13.
• 2、 Dhainaut, Alain,Regnier, Gilbert,Atassi, Ghanem,Pierre, Alain,Leonce, Stephane,et al.. "New Triazine Derivatives as Potent Modulators of Multidrug Resistance". . p. 2481 - 2496. Retrieved 2007/10/02.