9H-Fluorene-9-carboxylic acid amide

Base Information

• Chemical Name: 9H-Fluorene-9-carboxylic acid amide
• CAS No.: 7471-95-6
• Molecular Formula: C14H11NO
• Molecular Weight: 209.247
• Hs Code.: 2924299090
• Mol file: 7471-95-6.mol

Synonyms:Fluorene-9-carboxamide(6CI,7CI,8CI);9-(Aminocarbonyl)fluorene;9-Carbamoylfluorene;NSC 402240;

Chemical Property of 9H-Fluorene-9-carboxylic acid amide

Chemical Property:

• Vapor Pressure: 1.22E-08mmHg at 25°C
• Melting Point: 252-255 °C
• Refractive Index: 1.664
• Boiling Point: 459.9 °C at 760 mmHg
• PKA: 15.70±0.20(Predicted)
• Flash Point: 231.9 °C
• PSA: 43.09000
• Density: 1.254 g/cm³
• LogP: 2.98450

Purity/Quality:

98%min ^*data from raw suppliers

Fluorene-9-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fluorene-9-carboxamide is a derivative of Fluorene (F462000), which is a polycyclic aromatic hydrocarbons as micropollutants.

Technology Process of 9H-Fluorene-9-carboxylic acid amide

There total 12 articles about 9H-Fluorene-9-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

concentrated aqueous ammonium hydroxide + 9H-fluorene-9-carboxylic acid (1989-33-9) → 9H-fluorene-9-carboxamide (7471-95-6)

Guidance literature:

With thionyl chloride; In tetrachloromethane; acetone;

Reference yield: 16.0%

9H-fluorene-9-carboxylic acid (1989-33-9) → 9H-fluorene-9-carboxamide (7471-95-6)

Guidance literature:

9H-fluorene-9-carboxylic acid; With thionyl chloride; for 4h; Reflux; Inert atmosphere;

With ammonia; In water; at 0 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1039/c9ob02258a

Reference yield: 0.4%

dibromodifluoromethane (75-61-6) + N-(9H-fluoren-9-ylidene)-1-phenylmethanamine (70766-02-8) → 9H-fluorene-9-carboxamide (7471-95-6)

Guidance literature:

dibromodifluoromethane; N-(9H-fluoren-9-ylidene)-1-phenylmethanamine; With lead; tetrabutylammomium bromide; In dichloromethane; at 40 ℃; for 25h;

With water; silica gel;

DOI:10.1134/S1070428006120086

upstream raw materials:

9H-fluorene

9H-fluorene-9-carbonyl chloride

methyl 9H-fluorene-9-carboxylate

dibromodifluoromethane

Downstream raw materials:

9H-fluoren-9-ylmethanamine

9-aminocarbonyl-9-(2-cyanoethyl)fluorene

9H-fluorene-9-carboxylic acid

9H-fluorene-9-carbonitrile

Refernces

• 1、 Novikov,Khlebnikov,Egarmin,Shevchenko,Khlebnikov,Kostikov,Vidovic. "Regioselectivity of the 1,3-dipolar cycloaddition of fluorinated fluoren-9-iminium ylides to heteroelement-containing dipolarophiles: Experimental and quantum-chemical study". . p. 1800 - 1812. Retrieved 2007/10/03.
• 2、 -. "Urea, thiourea and guanidine compounds and their use as anti-viral agents". . . Retrieved 2008/06/13.