N-benzyloxycarbonyl-o-iodophenethylamine

Base Information

• Chemical Name: N-benzyloxycarbonyl-o-iodophenethylamine
• CAS No.: 434934-82-4
• Molecular Formula: C₁₆H₁₆INO₂
• Molecular Weight: 381.213
• Mol file: 434934-82-4.mol

Synonyms:N-benzyloxycarbonyl-o-iodophenethylamine

Chemical Property of N-benzyloxycarbonyl-o-iodophenethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonyl-o-iodophenethylamine

There total 3 articles about N-benzyloxycarbonyl-o-iodophenethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

benzyl chloroformate (501-53-1,94274-21-2) + 2-(2-iodophenyl)ethylamine hydrochloride → N-benzyloxycarbonyl-o-iodophenethylamine (434934-82-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

DOI:10.1021/jo300874m

Reference yield:

N-(2-(2-iodophenyl)ethyl)amine (66384-49-4) + benzyl chloroformate (501-53-1,94274-21-2) → N-benzyloxycarbonyl-o-iodophenethylamine (434934-82-4)

Guidance literature:

With pyridine; In acetonitrile; at 0 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tet.2008.09.042

Reference yield:

2-(2-iodophenyl)acetonitrile (40400-15-5) → N-benzyloxycarbonyl-o-iodophenethylamine (434934-82-4)

Guidance literature:

Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

2: triethylamine / tetrahydrofuran; methanol / 1 h / 20 °C

With borane-THF; triethylamine; In tetrahydrofuran; methanol;

DOI:10.1021/jo300874m

upstream raw materials:

N-(2-(2-iodophenyl)ethyl)amine

benzyl chloroformate

2-(2-iodophenyl)acetonitrile

Downstream raw materials:

N-(benzyloxycarbonyl)indoline

Refernces

• 1、 Kubo, Tetsuji,Katoh, Chiharu,Yamada, Ken,Okano, Kentaro,Tokuyama, Hidetoshi,Fukuyama, Tohru. "A mild inter- and intramolecular amination of aryl halides with a combination of CuI and CsOAc". supporting information; experimental part. p. 11230 - 11236. Retrieved 2009/04/11.