C₁₉H₁₈F₄N₂O₄S

Base Information

• Chemical Name: C₁₉H₁₈F₄N₂O₄S
• CAS No.: 1445792-92-6
• Molecular Formula: C₁₉H₁₈F₄N₂O₄S
• Molecular Weight: 446.423
• Mol file: 1445792-92-6.mol

Synonyms:C₁₉H₁₈F₄N₂O₄S

Chemical Property of C₁₉H₁₈F₄N₂O₄S

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₁₉H₁₈F₄N₂O₄S

There total 5 articles about C₁₉H₁₈F₄N₂O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.7%

4-methylpiperidin-4-ol (3970-68-1) + 2-fluoro-5-(3,4,5-trifluorophenylcarbamoyl)benzene-1-sulfonyl chloride (1445796-56-4) → C19H18F4N2O4S (1445792-92-6)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → C19H18F4N2O4S (1445792-92-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 3 h / 0 - 20 °C

2: 10 wt% Pd(OH)2 on carbon; hydrogen / methanesulfonic acid / 2585.81 Torr

3: triethylamine / acetonitrile / 1 h / 20 °C

With 10 wt% Pd(OH)2 on carbon; hydrogen; triethylamine; In tetrahydrofuran; methanesulfonic acid; acetonitrile;

Reference yield:

1-benzyl-4-methyl-piperidin-4-ol (3970-66-9) → C19H18F4N2O4S (1445792-92-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanesulfonic acid / 2585.81 Torr

2: triethylamine / acetonitrile / 1 h / 20 °C

With 10 wt% Pd(OH)2 on carbon; hydrogen; triethylamine; In methanesulfonic acid; acetonitrile;

upstream raw materials:

1-phenylmethyl-4-piperidone

1-benzyl-4-methyl-piperidin-4-ol

4-methylpiperidin-4-ol

2-fluoro-5-(3,4,5-trifluorophenylcarbamoyl)benzene-1-sulfonyl chloride

Refernces