2-(3-pyridyl)-3-(4-methoxyphenyl)-6-methoxyindene

Base Information

• Chemical Name: 2-(3-pyridyl)-3-(4-methoxyphenyl)-6-methoxyindene
• CAS No.: 114584-01-9
• Molecular Formula: C₂₂H₁₉NO₂
• Molecular Weight: 329.398
• Mol file: 114584-01-9.mol

Synonyms:2-(3-pyridyl)-3-(4-methoxyphenyl)-6-methoxyindene

Chemical Property of 2-(3-pyridyl)-3-(4-methoxyphenyl)-6-methoxyindene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-pyridyl)-3-(4-methoxyphenyl)-6-methoxyindene

There total 3 articles about 2-(3-pyridyl)-3-(4-methoxyphenyl)-6-methoxyindene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

1-(4-methoxyphenyl)-2-(3-pyridyl)-3-(3-methoxyphenyl)-1-propanone (114583-96-9) → 2-(3-pyridyl)-3-(4-methoxyphenyl)-6-methoxyindene (114584-01-9)

Guidance literature:

With methanesulfonic acid; In dichloromethane; at 25 ℃; for 0.5h;

DOI:10.1021/jm00117a014

Reference yield:

1-(4-methoxyphenyl)-2-(pyridin-3-yl)-ethanone (52700-25-1) → 2-(3-pyridyl)-3-(4-methoxyphenyl)-6-methoxyindene (114584-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / sodium hydride, LiI / dimethylformamide / 40 - 50 °C

2: 48 percent / methanesulfonic acid / CH₂Cl₂ / 0.5 h / 25 °C

With methanesulfonic acid; sodium hydride; lithium iodide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00117a014

Reference yield:

m-methoxybenzyl chloride (824-98-6) → 2-(3-pyridyl)-3-(4-methoxyphenyl)-6-methoxyindene (114584-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / sodium hydride, LiI / dimethylformamide / 40 - 50 °C

2: 48 percent / methanesulfonic acid / CH₂Cl₂ / 0.5 h / 25 °C

With methanesulfonic acid; sodium hydride; lithium iodide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00117a014

upstream raw materials:

1-(4-methoxyphenyl)-2-(3-pyridyl)-3-(3-methoxyphenyl)-1-propanone

1-(4-methoxyphenyl)-2-(pyridin-3-yl)-ethanone

m-methoxybenzyl chloride

Downstream raw materials:

2-(3-pyridyl)-3-(4-hydroxyphenyl)-6-hydroxyindene

Refernces