Formamide, N-(2-methyl-3-pyridinyl)- (9CI)

Base Information

• Chemical Name: Formamide, N-(2-methyl-3-pyridinyl)- (9CI)
• CAS No.: 116286-64-7
• Molecular Formula: C7H8 N2 O
• Molecular Weight: 136.153
• Mol file: 116286-64-7.mol

Synonyms:3-(Formylamino)-2-methylpyridine

Chemical Property of Formamide, N-(2-methyl-3-pyridinyl)- (9CI)

Chemical Property:

• PSA: 41.99000
• LogP: 1.66720

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Formamide, N-(2-methyl-3-pyridinyl)- (9CI)

There total 2 articles about Formamide, N-(2-methyl-3-pyridinyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-methyl-3-pyridinamine (3430-10-2) + carbon dioxide (124-38-9,18923-20-1) → N-(2-methyl-[3]pyridyl)-formamide (116286-64-7)

Guidance literature:

With sodium (phenyltrihydroxyborate); phenylsilane; In diethylene glycol dimethyl ether; at 60 ℃; for 12h; under 1875.19 Torr; Sealed tube; Glovebox; Autoclave;

DOI:10.1039/d0gc01741h

Reference yield:

2-methyl-3-pyridinamine (3430-10-2) + formic acid (64-18-6) → N-(2-methyl-[3]pyridyl)-formamide (116286-64-7)

Guidance literature:

With diethyl ether; acetic anhydride;

DOI:10.1039/jr9480000198

Reference yield:

N-(2-methyl-[3]pyridyl)-formamide (116286-64-7) → 1H-pyrrolo[3,2-b]pyridine (272-49-1)

Guidance literature:

With potassium ethoxide; at 350 ℃;

DOI:10.1039/jr9480000198

upstream raw materials:

2-methyl-3-pyridinamine

formic acid

carbon dioxide

Downstream raw materials:

1H-pyrrolo[3,2-b]pyridine

Refernces