Ethyl 2-Morpholinoacetate

Base Information

• Chemical Name: Ethyl 2-Morpholinoacetate
• CAS No.: 3235-82-3
• Molecular Formula: C8H15NO3
• Molecular Weight: 173.212
• Hs Code.: 29349990
• DSSTox Substance ID: DTXSID90370128
• Nikkaji Number: J1.845.688E
• Wikidata: Q82157436
• ChEMBL ID: CHEMBL1190168
• Mol file: 3235-82-3.mol

Synonyms:Ethyl 2-Morpholinoacetate;3235-82-3;Ethyl 2-morpholin-4-ylacetate;4-Morpholineacetic acid, ethyl ester;Ethyl morpholin-4-ylacetate;ETHYL MORPHOLINOACETATE;MFCD00023375;Morpholin-4-yl-acetic acid ethyl ester;ethyl 4-morpholineacetate;ethyl-2-morpholinoacetate;ethyl 4-morpholinylacetate;Ethyl morpholinoacetate,98;SCHEMBL2909869;CHEMBL1190168;Morpholinoacetic acid ethyl ester;DTXSID90370128;SITMDWHJQROIPF-UHFFFAOYSA-N;4-(Ethoxycarbonylmethyl)morpholine;AMY20473;STL582183;AKOS003973589;AC-7245;AS-31747;SY005320;BB 0257891;CS-0067772;FT-0683895;A875643

Chemical Property of Ethyl 2-Morpholinoacetate

Chemical Property:

• Appearance/Colour: clear light yellow liquid
• Vapor Pressure: 0.0519mmHg at 25°C
• Boiling Point: 234.793 °C at 760 mmHg
• PKA: 5.06±0.10(Predicted)
• Flash Point: 95.8 °C
• PSA: 38.77000
• Density: 1.065 g/cm³
• LogP: -0.18040
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 173.10519334
• Heavy Atom Count: 12
• Complexity: 143

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl2-Morpholinoacetate ^*data from reagent suppliers

Safty Information:

• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CN1CCOCC1

Technology Process of Ethyl 2-Morpholinoacetate

There total 11 articles about Ethyl 2-Morpholinoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + ethyl bromoacetate (105-36-2) → N-morpholylacetic acid ethyl ester (3235-82-3)

Guidance literature:

In benzene; for 0.5h; Reflux;

DOI:10.1055/s-0030-1259282

Reference yield: 95.0%

morpholine (110-91-8,99108-56-2) + diazoacetic acid ethyl ester (623-73-4) → N-morpholylacetic acid ethyl ester (3235-82-3)

Guidance literature:

With 5,10,15,20-tetraphenyl-21H,23H-porphine iron(lll) chloride; In diethyl ether; for 0.0833333h;

DOI:10.1002/chem.200701885

Reference yield: 91.0%

morpholine (110-91-8,99108-56-2) + chloroacetic acid ethyl ester (105-39-5) → N-morpholylacetic acid ethyl ester (3235-82-3)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; at 20 ℃; Neat (no solvent);

DOI:10.1080/00397910802654740

upstream raw materials:

morpholine

chloroacetic acid ethyl ester

ethyl bromoacetate

4-morpholinoacetonitrile

Downstream raw materials:

1,1-bis-(4-chloro-phenyl)-2-morpholin-4-yl-ethanol

2-(4-morpholinyl)acetylhydrazine

(morpholinyl-4)methyl-1 cyclopentanol

morpholin-4-ylacetic acid

Refernces

• 1、 Perekalin, Dmitry S.,Shvydkiy, Nikita V.. "Cyclobutadiene cobalt complexes as catalysts for insertion of diazo compounds into X–H bonds". . p. 350 - 351. Retrieved 2021/06/07.
• 2、 Fasan, Rudi,Sreenilayam, Gopeekrishnan,Steck, Viktoria. "Selective Functionalization of Aliphatic Amines via Myoglobin-Catalyzed Carbene N-H Insertion". supporting information. p. 224 - 229. Retrieved 2020/02/15.