C₁₈H₁₃F₃N₄S

Base Information

• Chemical Name: C₁₈H₁₃F₃N₄S
• CAS No.: 1613132-81-2
• Molecular Formula: C₁₈H₁₃F₃N₄S
• Molecular Weight: 374.389
• Mol file: 1613132-81-2.mol

Synonyms:C₁₈H₁₃F₃N₄S

Chemical Property of C₁₈H₁₃F₃N₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₈H₁₃F₃N₄S

There total 4 articles about C₁₈H₁₃F₃N₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H11ClF3NO (1613132-75-4) + thiosemicarbazide (79-19-6) → C18H13F3N4S (1613132-81-2)

Guidance literature:

With sodium hydroxide; In ethanol; for 8h; Reflux;

DOI:10.1016/j.ejmech.2014.04.043

Reference yield:

2-phenyl-5-(trifluoromethyl)-1H-indole (491601-38-8) → C18H13F3N4S (1613132-81-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / toluene / Reflux

2: sodium hydroxide / ethanol / 8 h / Reflux

With potassium carbonate; sodium hydroxide; In ethanol; toluene;

DOI:10.1016/j.ejmech.2014.04.043

Reference yield:

α-bromoacetophenone (70-11-1) → C18H13F3N4S (1613132-81-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: neat (no solvent) / 3 h / 20 °C / Green chemistry

1.2: 255 / 0.02 h / Microwave irradiation; Green chemistry

2.1: potassium carbonate / toluene / Reflux

3.1: sodium hydroxide / ethanol / 8 h / Reflux

With potassium carbonate; sodium hydroxide; In ethanol; toluene; 1.1: |Bischler-Moehlau Indole Synthesis / 1.2: |Bischler-Moehlau Indole Synthesis;

DOI:10.1016/j.ejmech.2014.04.043

upstream raw materials:

2-phenyl-5-(trifluoromethyl)-1H-indole

C₁₇H₁₁ClF₃NO

thiosemicarbazide

α-bromoacetophenone

Downstream raw materials:

C₁₈H₁₄F₃N₅S

6-(3-allyl-2-phenyl-5-(trifluoromethyl)-1H-indol-1-yl)-5-amino-4,5-dihydro-1,2,4-triazine-3(2H)-thione

1-(1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-2-phenyl-5-(trifluoromethyl)-1H-indol-3-yl)ethanone

1-(5-amino-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)-2-phenyl-5-(trifluoromethyl)-1H-indole-3-carboxylic acid

Refernces