2-iodo-4-nitrobenzoyl chloride

Base Information

• Chemical Name: 2-iodo-4-nitrobenzoyl chloride
• CAS No.: 861602-59-7
• Molecular Formula: C₇H₃ClINO₃
• Molecular Weight: 311.463
• Mol file: 861602-59-7.mol

Synonyms:2-iodo-4-nitrobenzoyl chloride

Chemical Property of 2-iodo-4-nitrobenzoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-iodo-4-nitrobenzoyl chloride

There total 4 articles about 2-iodo-4-nitrobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-2-iodobenzoic acid (89459-38-1) → 2-iodo-4-nitrobenzoyl chloride (861602-59-7)

Guidance literature:

With phosphorus pentachloride;

Reference yield:

2-iodo-1-methyl-4-nitrobenzene (7745-92-8) → 2-iodo-4-nitrobenzoyl chloride (861602-59-7)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid / 110 - 115 °C / im Druckrohr

2: PCl₅

With phosphorus pentachloride; nitric acid;

Reference yield:

4-nitro-2-iodosobenzoic acid (112391-34-1) → 2-iodo-4-nitrobenzoyl chloride (861602-59-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium iodide / water; acetic acid / 1.08 - 1.17 h / 23 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 23 °C

With oxalyl dichloride; potassium iodide; N,N-dimethyl-formamide; In dichloromethane; water; acetic acid;

upstream raw materials:

4-nitro-2-iodobenzoic acid

4-Nitroanthranilic acid

2-iodo-1-methyl-4-nitrobenzene

4-nitro-2-iodosobenzoic acid

Downstream raw materials:

2-iodo-4-nitrobenzamide

6-nitro-3-phenyl-1,2-benzisoxazole

4-[4,4-dimethyl-3-(4-hydroxybutyl)-5-imino-2-thioxo-1-imidazoldinyl]-2-iodobenzonitrile

DTIB

Refernces

• 1、 Nair, Vipin A.,Mustafa, Suni M.,Mohler, Michael L.,Fisher, Scott J.,Dalton, James T.,Miller, Duane D.. "Synthesis of novel iodo derived bicalutamide analogs". . p. 9475 - 9477. Retrieved 2007/10/03.
• 2、 Hammond, Marlys,Elliott, Richard L.,Gillaspy, Melissa L.,Hager, David C.,Hank, Richard F.,LaFlamme, Janet A.,Oliver, Robert M.,DaSilva-Jardine, Paul A.,Stevenson, Ralph W.,Mack, Christine M.,Cassella, James V.. "Structure-activity relationships in a series of NPY Y5 antagonists: 3-Amido-9-ethylcarbazoles, core-modified analogues and amide isosteres". . p. 1989 - 1992. Retrieved 2007/10/03.