1-chloro-2-ethoxy-4-nitrobenzene

Base Information

• Chemical Name: 1-chloro-2-ethoxy-4-nitrobenzene
• CAS No.: 102236-22-6
• Molecular Formula: C₈H₈ClNO₃
• Molecular Weight: 201.609
• Mol file: 102236-22-6.mol

Synonyms:1-chloro-2-ethoxy-4-nitrobenzene

Chemical Property of 1-chloro-2-ethoxy-4-nitrobenzene

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-Chloro-2-ethoxy-4-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-chloro-2-ethoxy-4-nitrobenzene

There total 13 articles about 1-chloro-2-ethoxy-4-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-nitro-2-chlorophenol (619-10-3) + ethyl iodide (75-03-6) → 1-chloro-2-ethoxy-4-nitrobenzene (102236-22-6)

Guidance literature:

5-nitro-2-chlorophenol; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.166667h;

ethyl iodide; In DMF (N,N-dimethyl-formamide); for 72h;

Reference yield: 58.0%

tetraethoxy orthosilicate (78-10-4) + potassium 2-chloro-5-nitrobenzoate → 1-chloro-2-ethoxy-4-nitrobenzene (102236-22-6)

Guidance literature:

With oxygen; copper diacetate; silver carbonate; In N,N-dimethyl-formamide; at 145 ℃; for 18h;

DOI:10.1021/ja304539j

Reference yield:

2,4-Dinitroanilin (97-02-9) → 1-chloro-2-ethoxy-4-nitrobenzene (102236-22-6)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOCl, KOH / H₂O

2: Cu, aq. HCl

3: (i) NaNO₂, H₂SO₄, (ii) aq. H₃PO₂

With hydrogenchloride; potassium hydroxide; sodium hypochlorite; copper; In water;

DOI:10.1021/jo01032a029

upstream raw materials:

5-nitro-2-amino-phenetole

4-ethoxy-5-chloro-2-nitro-aniline

3-Chlor-2-aethoxy-5-nitro-anilin

2'-ethoxyacetanilide

Downstream raw materials:

4-chloro-3-ethoxy-benzaldehyde

(E)-3-(4-Chloro-3-ethoxy-phenyl)-acrylic acid

5-(4-Chloro-3-ethoxy-phenyl)-thiazolidine-2,4-dione

4-chloro-3-ethoxyphenylamine

Refernces

• 1、 Bhadra, Sukalyan,Dzik, Wojciech I.,Goossen, Lukas J.. "Decarboxylative etherification of aromatic carboxylic acids". supporting information; experimental part. p. 9938 - 9941. Retrieved 2012/08/08.