619-10-3

Basic information

• Product Name: 2-Chloro-5-nitrophenol
• Synonyms: TIMTEC-BB SBB001524;2-CHLORO-5-NITROPHENOL;2-choro-5-nitrophenol;5-Nitro-2-Chlorophenol;2-Chloro-5-nitrophen;4-Chloro-3-hydroxynitrobenzene;NSC 212119;Phenol, 2-chloro-5-nitro-
• CAS NO: 619-10-3
• Molecular Formula: C₆H₄ClNO₃
• Molecular Weight: 173.55
• EINECS: 210-579-3
• Product Categories: Aromatic Phenols;Phenol&Thiophenol&Mercaptan;Phenoles and thiophenoles;Aromatics
• Mol File: 619-10-3.mol
• Article Data: 22

Chemical Properties

• Melting Point: 118-121°C
• Boiling Point: 276.1 °C at 760 mmHg
• Flash Point: 120.8 °C
• Appearance: yellow powder
• Density: 1.554 g/cm³
• Vapor Pressure: 0.0029mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
• PKA: 6.72±0.19(Predicted)
• CAS DataBase Reference: 2-Chloro-5-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-nitrophenol(619-10-3)
• EPA Substance Registry System: 2-Chloro-5-nitrophenol(619-10-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 619-10-3(Hazardous Substances Data)

Usage

Uses

2-Chloro-5-nitrophenol (cas# 619-10-3) is a compound useful in organic synthesis.

InChI:InChI=1/C6H4ClNO3/c7-5-2-1-4(8(10)11)3-6(5)9/h1-3,9H

Upstream product

• 554-84-7 meta-nitrophenol 
• 1351353-49-5 1-chloro-2-((4-methoxybenzyl)oxy)-4-nitrobenzene 
• 7758-89-6 copper(I) chloride 
• 5329-14-6 aminosulfonic acid 
• 7440-44-0 pyrographite 
• 121-88-0 5-Nitro-2-aminophenol 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 4920-79-0 2-chloro-4-nitroanisole 
• 51-19-4 2-aminophenol hydrochloride 
• 861086-20-6 acetic acid-(4-ethoxy-5-chloro-2-nitro-anilide) 
• 171111-66-3 4-ethoxy-5-chloro-2-nitro-aniline 
• 108761-49-5 acetic acid-(4-ethoxy-3-chloro-anilide) 
• 304667-95-6 2-acetoxy-1-acetylamino-4-nitro-benzene 
• 5467-64-1 2-acetamidophenyl acetate 

Downstream Products

• 191984-82-4 1-chloro-2-(3-methyl-2-butenyloxy)-4-nitrobenzene 
• 1009-36-5 2-chloro-5-nitroanisole 
• 357405-72-2 [3-(2-Chloro-5-nitrophenoxy)-3-phenylpropyl]methylcarbamic acid 1,1-dimethylethyl ester 
• 102236-22-6 1-chloro-2-ethoxy-4-nitrobenzene 
• 1351353-49-5 1-chloro-2-((4-methoxybenzyl)oxy)-4-nitrobenzene 
• 191984-84-6 4-chloro-3-(3-methyl-2-butenyloxy)-benzenamine 
• 856676-69-2 Benzoic acid (2S,5R)-5-{5-[3-(6-{3-[4-chloro-3-(3-methyl-but-2-enyloxy)-phenylcarbamoyl]-furan-2-yl}-hexyloxy)-prop-1-ynyl]-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl}-2,5-dihydro-furan-2-ylmethyl ester 
• 856676-66-9 2-(6-prop-2-ynyloxy-hexyl)-furan-3-carboxylic acid [4-chloro-3-(3-methyl-but-2-enyloxy)-phenyl]-amide 
• 876314-53-3 {2-[4-chloro-3-(3-methyl-but-2-enyloxy)-phenylamino]-pyrimidin-4-yl}-methanol 
• 876314-63-5 2-chloro-5-(4-hydroxymethyl-pyrimidin-2-ylamino)-phenol 

Relevant articles and documents

Effect of chloride ion concentration on rapid kinetics of chlorination of regioisomers of nitrophenol by molecular chlorine in aqueous medium using rotating platinum electrode

The rapid kinetics of chlorination of regioisomers of the nitrophenol by molecular chlorine in the presence of chloride ion in aqueous solution has been studied using rotating platinum electrode (RPE). The chloride ion has a catalytic effect on the chlorination reaction. The mechanism suggested explaining the catalytic effect of chloride ion postulates a longer mean life for Cl-Cl dipole induced by the aromatic substrate by electron rearrangement with the chloride ion, which facilitate the electrophilic attack of Cl-Cl on the aromatic substrate in rate determining step. Hence the specific reaction rate varies linearly with the concentration of chloride ion.

ANTI-INFLAMMATORY COMPOUND HAVING INHIBITORY ACTIVITY AGAINST MULTIPLE TYROSINE KINASES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

The present invention is for the anti-inflammatory compounds that have an inhibitory activity against protein tyrosine kinases and their pharmaceutical composition(s) containing the compound as the active ingredient. Since the compounds of the present invention can inhibit multiple protein kinases associated with inflammatory diseases and immune disorders, they are useful for their prevention or treatment.

COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION

Compounds of the formula (I) are provided, including pharmaceutically acceptable salts thereof: which modulate β-amyloid peptide (β-AP) production, and are useful in the treatment of Alzheimer's Disease and other conditions affected by -amyloid peptide (β-AP) production.