191984-82-4Relevant articles and documents
New methodology for 2-alkylation of 3-furoic acids: Application to the synthesis of tethered UC-781/d4T bifunctional HIV reverse-transcriptase inhibitors
Arnott, Gareth,Hunter, Roger,Mbeki, Linda,Mohamed, Ebrahim
, p. 4023 - 4026 (2005)
New methodology for 2-alkylation of 3-furoic acids is presented involving Wittig reactions of the 3-methoxycarbonyl-2-furanylmethylphosphonium salt. The methodology has been used to prepare a tethered 2-alkylated-UC-781/d4T conjugate as a potentially new type of HIV reverse-transcriptase inhibitor.
Compounds useful for the inhibition of the replication of HIV-1 and HIV-1 mutants
-
, (2008/06/13)
Compounds of the formula STR1 wherein X is O or S, useful for the inhibition of the replication of HIV-1 and reverse transcriptase mutants thereof, in vitro and in vivo.