Technology Process of C20H15FN2O
There total 5 articles about C20H15FN2O which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C8H4(OCH2C6H5)(NCOOC(CH3)3)BF3(1-)*K(1+)=C8H4(OCH2C6H5)(NCOOC(CH3)3)BF3K; 2-bromo-5-fluoropyridine;
With
sodium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; water;
Heating;
With
silica gel;
In
dichloromethane;
at 80 ℃;
Further stages.;
DOI:10.1039/b700433h
- Guidance literature:
-
1-tert-butyloxycarbonyl-5-benzyloxy-indole-2-boronic acid; 2-bromo-5-fluoropyridine;
With
sodium carbonate;
bis(triphenylphosphine)palladium(II)-chloride;
In
1,2-dimethoxyethane; water;
Heating;
With
silica gel;
In
dichloromethane;
at 80 ℃;
Further stages.;
DOI:10.1039/b700433h
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 93 percent / (dimethylamino)pyridine / tetrahydrofuran / 20 °C
2.1: triisopropyl borate / tetrahydrofuran / 0 °C
2.2: 99 percent / lithium diisopropylamide / heptane; tetrahydrofuran; ethylbenzene / 0.5 h / 0 °C
3.1: Na2CO3 / bis(triphenylphosphine)palladium(II) chloride / 1,2-dimethoxy-ethane; H2O / Heating
3.2: 57 percent / silica gel / CH2Cl2 / 80 °C
With
dmap; Triisopropyl borate; sodium carbonate;
bis(triphenylphosphine)palladium(II)-chloride;
In
tetrahydrofuran; 1,2-dimethoxyethane; water;
3.1: Suzuki cross-coupling reaction;
DOI:10.1039/b700433h
