Pyridine, 3-(3-bromopropyl)- (9CI)

Base Information

• Chemical Name: Pyridine, 3-(3-bromopropyl)- (9CI)
• CAS No.: 109839-74-9
• Molecular Formula: C8H10 Br N
• Molecular Weight: 200.078
• Hs Code.: 2933399090
• Mol file: 109839-74-9.mol

Synonyms:1-Bromo-3-(3-pyridinyl)propane;3-(3-Bromopropyl)pyridine; 3-(3-Pyridyl)-1-bromopropane

Chemical Property of Pyridine, 3-(3-bromopropyl)- (9CI)

Chemical Property:

• Vapor Pressure: 0.041mmHg at 25°C
• Refractive Index: 1.55
• Boiling Point: 247.15°C at 760 mmHg
• PKA: 5.36±0.10(Predicted)
• Flash Point: 103.273°C
• PSA: 12.89000
• Density: 1.378g/cm³
• LogP: 3.36720

Purity/Quality:

98%min ^*data from raw suppliers

3-(3-Bromopropyl)pyridine hydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 3-(3-bromopropyl)- (9CI)

There total 4 articles about Pyridine, 3-(3-bromopropyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-(3-pyridyl)propan-1-ol (2859-67-8) → 3-(3-bromopropyl)pyridine (109839-74-9)

Guidance literature:

With 1H-imidazole; triphenylphosphine; 2,3,5-tribromoimidazole; In toluene; for 2h; Heating;

DOI:10.1016/S0957-4166(97)00025-6

Reference yield:

methyl (E)-3-(3-pyridyl)acrylate (81124-48-3) → 3-(3-bromopropyl)pyridine (109839-74-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 10 percent Pd/C / tetrahydrofuran / 2068.59 Torr

2: LiAlH₄ / tetrahydrofuran / 3 h / Heating

3: CBr₄; Ph₃P / CH₂Cl₂ / 24 h / 0 °C

With lithium aluminium tetrahydride; carbon tetrabromide; hydrogen; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm010556c

Reference yield:

methyl 3-(3-pyridyl)propanoate (84199-98-4) → 3-(3-bromopropyl)pyridine (109839-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 3 h / Heating

2: CBr₄; Ph₃P / CH₂Cl₂ / 24 h / 0 °C

With lithium aluminium tetrahydride; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm010556c

upstream raw materials:

3-(3-pyridyl)propan-1-ol

methyl 3-(3-pyridyl)propanoate

methyl (E)-3-(3-pyridyl)acrylate

Downstream raw materials:

3-(pyridin-3'-yl)propanethiol

Br^(1-)*C₂₉H₄₀N₃O₂⁽¹⁺⁾

4,5-dimethyl-N-(3-pyridin-3-ylpropyl)benzene-1,2-diamine

4,5-dimethyl-2-nitro-N-(3-pyridin-3-ylpropyl)aniline

Refernces

• 1、 McCallum, Terry,Slavko, Ekaterina,Morin, Mathieu,Barriault, Louis. "Light-mediated deoxygenation of alcohols with a dimeric gold catalyst". supporting information. p. 81 - 85. Retrieved 2015/02/18.
• 2、 Hamilton, Gregory S.,Wu, Yong-Qian,Limburg, David C.,Wilkinson, Douglas E.,Vaal, Mark J.,Li, Jia-He,Thomas, Christine,Huang, Wei,Sauer, Hansjorg,Ross, Douglas T.,Soni, Raj,Chen, Yi,Guo, Hongshi,Howorth, Pamela,Valentine, Heather,Liang, Shi,Spicer, Dawn,Fuller, Mike,Steiner, Joseph P.. "Synthesis of N-glyoxyl prolyl and pipecolyl amides and thioesters and evaluation of their in vitro and in vivo nerve regenerative effects". . p. 3549 - 3557. Retrieved 2007/10/03.