4-methyl-N-((4-hydroxyphenyl)(morpholino)methylene)benzensulfonamide

Base Information

• Chemical Name: 4-methyl-N-((4-hydroxyphenyl)(morpholino)methylene)benzensulfonamide
• CAS No.: 1321807-47-9
• Molecular Formula: C₁₈H₂₀N₂O₄S
• Molecular Weight: 360.434
• Mol file: 1321807-47-9.mol

Synonyms:4-methyl-N-((4-hydroxyphenyl)(morpholino)methylene)benzensulfonamide

Chemical Property of 4-methyl-N-((4-hydroxyphenyl)(morpholino)methylene)benzensulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-N-((4-hydroxyphenyl)(morpholino)methylene)benzensulfonamide

There total 4 articles about 4-methyl-N-((4-hydroxyphenyl)(morpholino)methylene)benzensulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-(p-tolylsulfonyl)-2-phenylaziridine (24395-14-0) + (4-hydroxyphenyl)-4-morpholinylmethanethione (3202-77-5) → 4-methyl-N-((4-hydroxyphenyl)(morpholino)methylene)benzensulfonamide (1321807-47-9)

Guidance literature:

N-(p-tolylsulfonyl)-2-phenylaziridine; With zinc(II) chloride; In dichloromethane; at 40 ℃; for 0.0833333h;

(4-hydroxyphenyl)-4-morpholinylmethanethione; In dichloromethane; at 40 ℃; for 2h;

DOI:10.1055/s-0034-1378376

Reference yield: 61.0%

4-toluenesulfonyl azide (941-55-9) + C12H15NO2 (1321807-30-0) → 4-methyl-N-((4-hydroxyphenyl)(morpholino)methylene)benzensulfonamide (1321807-47-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.333333h;

DOI:10.1055/s-0030-1260548

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-methyl-N-((4-hydroxyphenyl)(morpholino)methylene)benzensulfonamide (1321807-47-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfur

2.1: zinc(II) chloride / dichloromethane / 0.08 h / 40 °C

2.2: 2 h / 40 °C

With sulfur; zinc(II) chloride; In dichloromethane; 1.1: |Willgerodt-Kindler Rearrangement;

DOI:10.1055/s-0034-1378376

upstream raw materials:

4-toluenesulfonyl azide

C₁₂H₁₅NO₂

N-(p-tolylsulfonyl)-2-phenylaziridine

(4-hydroxyphenyl)-4-morpholinylmethanethione

Refernces

• 1、 Gao, Tingting,Zhao, Mingming,Meng, Xu,Li, Chuanbin,Chen, Baohua. "Facile synthesis of sulfonyl amidines and β-amino sulfonyl enamines under transition-metal-free conditions". experimental part. p. 1281 - 1284. Retrieved 2011/08/03.