Thiazolo[5,4-c]pyridin-2-amine

Base Information

• Chemical Name: Thiazolo[5,4-c]pyridin-2-amine
• CAS No.: 108310-79-8
• Molecular Formula: C6H5N3S
• Molecular Weight: 151.19
• Hs Code.: 2934999090
• European Community (EC) Number: 959-515-2
• DSSTox Substance ID: DTXSID30549831
• Nikkaji Number: J2.276.199D
• Wikidata: Q72508296
• Mol file: 108310-79-8.mol

Synonyms:thiazolo[5,4-c]pyridin-2-amine;108310-79-8;Thiazolo[5,4-c]pyridin-2-ylamine;[1,3]thiazolo[5,4-c]pyridin-2-amine;MFCD09909658;SCHEMBL14858961;AMY1780;DTXSID30549831;CL3446;AKOS015854294;GS-6362;PB34487;AC-23281;SY069183;CS-0053689;A895280;J-524918

Chemical Property of Thiazolo[5,4-c]pyridin-2-amine

Chemical Property:

• Refractive Index: 1.785
• Boiling Point: 350.3 °C at 760 mmHg
• PKA: 4.01±0.50(Predicted)
• Flash Point: 165.7 °C
• PSA: 80.04000
• Density: 1.485 g/cm³
• LogP: 1.85470
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 151.02041835
• Heavy Atom Count: 10
• Complexity: 130

Purity/Quality:

99% ^*data from raw suppliers

Thiazolo[5,4-c]pyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC2=C1N=C(S2)N

Technology Process of Thiazolo[5,4-c]pyridin-2-amine

There total 1 articles about Thiazolo[5,4-c]pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

thiazolo[5,4-c]-pyridine (273-70-1) + potassium selenocyanate (3425-46-5) → thiazolo[5,4-c]pyridin-2-ylamine (108310-79-8)

Guidance literature:

With trifluoromethylsulfonic anhydride; [bis(acetoxy)iodo]benzene; iodine; In water; at 110 ℃; for 6h; Sealed tube; Green chemistry;

DOI:10.1016/j.cclet.2021.08.070

Reference yield: 40.0%

thiazolo[5,4-c]pyridin-2-ylamine (108310-79-8) + 2-(4-(N-(pyridin-2-yl)sulfamoyl)phenyl)cyclopropane-1-carboxylic acid → 2-(4-(N-(pyridin-2-yl)sulfamoyl)phenyl)-N-(thiazolo[5,4-c]pyridin-2-yl)cyclopropane-1-carboxamide

Guidance literature:

With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; Inert atmosphere;

upstream raw materials:

thiazolo[5,4-c]-pyridine

potassium selenocyanate

Refernces