benzyl (1E)-2-(4-methylphenyl)prop-1-en-1-yl sulfone

Base Information

• Chemical Name: benzyl (1E)-2-(4-methylphenyl)prop-1-en-1-yl sulfone
• CAS No.: 1393559-77-7
• Molecular Formula: C₁₇H₁₈O₂S
• Molecular Weight: 286.395
• Mol file: 1393559-77-7.mol

Synonyms:benzyl (1E)-2-(4-methylphenyl)prop-1-en-1-yl sulfone

Chemical Property of benzyl (1E)-2-(4-methylphenyl)prop-1-en-1-yl sulfone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (1E)-2-(4-methylphenyl)prop-1-en-1-yl sulfone

There total 3 articles about benzyl (1E)-2-(4-methylphenyl)prop-1-en-1-yl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1-(benzylsulfonyl)-2-(4-methylphenyl)propan-2-ol (339276-91-4) → benzyl (1E)-2-(4-methylphenyl)prop-1-en-1-yl sulfone (1393559-77-7)

Guidance literature:

1-(benzylsulfonyl)-2-(4-methylphenyl)propan-2-ol; With dmap; triethylamine; trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In dichloromethane; Inert atmosphere;

DOI:10.1021/ja306731u

Reference yield:

2-(benzylsulfanyl)-1-(4-methylphenyl)ethanone (52264-86-5) → benzyl (1E)-2-(4-methylphenyl)prop-1-en-1-yl sulfone (1393559-77-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: cerium(III) chloride / tetrahydrofuran / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

3.1: dmap; triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C / Inert atmosphere

3.2: Inert atmosphere

With dmap; cerium(III) chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja306731u

Reference yield:

phenylmethanethiol (100-53-8) → benzyl (1E)-2-(4-methylphenyl)prop-1-en-1-yl sulfone (1393559-77-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / ethanol / 20 °C / Inert atmosphere

2.1: cerium(III) chloride / tetrahydrofuran / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

4.1: dmap; triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C / Inert atmosphere

4.2: Inert atmosphere

With dmap; cerium(III) chloride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/ja306731u

upstream raw materials:

2-(benzylsulfanyl)-1-(4-methylphenyl)ethanone

1-(benzylsulfonyl)-2-(4-methylphenyl)propan-2-ol

phenylmethanethiol

Downstream raw materials:

benzyl 2-(4-methylphenyl)propyl sulfone

Refernces