benzyl 2-(4-methylphenyl)propyl sulfone

Base Information

• Chemical Name: benzyl 2-(4-methylphenyl)propyl sulfone
• CAS No.: 1393560-05-8
• Molecular Formula: C₁₇H₂₀O₂S
• Molecular Weight: 288.411
• Mol file: 1393560-05-8.mol

Synonyms:

Chemical Property of benzyl 2-(4-methylphenyl)propyl sulfone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 2-(4-methylphenyl)propyl sulfone

There total 3 articles about benzyl 2-(4-methylphenyl)propyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl (1E)-2-(4-methylphenyl)prop-1-en-1-yl sulfone (1393559-77-7) → benzyl 2-(4-methylphenyl)propyl sulfone (1393560-05-8,1393561-60-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; under 1500.15 Torr;

DOI:10.1021/ja306731u

Reference yield:

2-(benzylsulfanyl)-1-(4-methylphenyl)ethanone (52264-86-5) → benzyl 2-(4-methylphenyl)propyl sulfone (1393560-05-8,1393561-60-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: cerium(III) chloride / tetrahydrofuran / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

3.1: dmap; triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / methanol / 1500.15 Torr

With dmap; cerium(III) chloride; palladium 10% on activated carbon; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/ja306731u

Reference yield:

phenylmethanethiol (100-53-8) → benzyl 2-(4-methylphenyl)propyl sulfone (1393560-05-8,1393561-60-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / ethanol / 20 °C / Inert atmosphere

2.1: cerium(III) chloride / tetrahydrofuran / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

4.1: dmap; triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: palladium 10% on activated carbon; hydrogen / methanol / 1500.15 Torr

With dmap; cerium(III) chloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1021/ja306731u

upstream raw materials:

2-(benzylsulfanyl)-1-(4-methylphenyl)ethanone

benzyl (1E)-2-(4-methylphenyl)prop-1-en-1-yl sulfone

phenylmethanethiol

Refernces