2-benzenesulfonyl-2,2-difluoro-1,1-diphenyl-ethanol

Base Information

• Chemical Name: 2-benzenesulfonyl-2,2-difluoro-1,1-diphenyl-ethanol
• CAS No.: 861721-58-6
• Molecular Formula: C₂₀H₁₆F₂O₃S
• Molecular Weight: 374.408
• Mol file: 861721-58-6.mol

Synonyms:2-benzenesulfonyl-2,2-difluoro-1,1-diphenyl-ethanol

Chemical Property of 2-benzenesulfonyl-2,2-difluoro-1,1-diphenyl-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-benzenesulfonyl-2,2-difluoro-1,1-diphenyl-ethanol

There total 1 articles about 2-benzenesulfonyl-2,2-difluoro-1,1-diphenyl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

benzophenone (119-61-9) + difluoromethyl phenyl sulfone (1535-65-5) → 2-benzenesulfonyl-2,2-difluoro-1,1-diphenyl-ethanol (861721-58-6)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 3h;

DOI:10.1002/ejoc.200500101

Reference yield: 82.0%

2-benzenesulfonyl-2,2-difluoro-1,1-diphenyl-ethanol (861721-58-6) → 1,1-Difluoro-2-hydroxy-2,2-diphenylethane (337-53-1)

Guidance literature:

With disodium hydrogenphosphate; sodium amalgam; In methanol; at -20 - -10 ℃; for 2h;

DOI:10.1002/ejoc.200500101

Reference yield:

2-benzenesulfonyl-2,2-difluoro-1,1-diphenyl-ethanol (861721-58-6) → N-(2,2-difluoro-1,1-diphenylethyl)acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂HPO₄; Na/Hg amalgam / methanol / -20 - 0 °C

2: 82 percent / concd. sulfuric acid / 3 h / Heating

With disodium hydrogenphosphate; sodium amalgam; sulfuric acid; In methanol; 2: Ritter reaction;

DOI:10.1016/j.tetlet.2006.07.079

upstream raw materials:

benzophenone

difluoromethyl phenyl sulfone

Downstream raw materials:

1,1-Difluoro-2-hydroxy-2,2-diphenylethane

Refernces

• 1、 Prakash, G.K.Surya,Hu, Jinbo,Wang, Ying,Olah, George A.. "Convenient synthesis of difluoromethyl alcohols from both enolizable and non-enolizable carbonyl compounds with difluoromethyl phenyl sulfone". . p. 2218 - 2223. Retrieved 2007/10/03.