3-(1-piperidinomethyl)-anisole

Base Information

• Chemical Name: 3-(1-piperidinomethyl)-anisole
• CAS No.: 107417-55-0
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.3
• Mol file: 107417-55-0.mol

Synonyms:3-(1-piperidinomethyl)-anisole

Chemical Property of 3-(1-piperidinomethyl)-anisole

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(1-piperidinomethyl)-anisole

There total 12 articles about 3-(1-piperidinomethyl)-anisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-Formylpiperidine (2591-86-8) + m-methoxybenzyl chloride (824-98-6) → 3-(1-piperidinomethyl)-anisole (107417-55-0)

Guidance literature:

With potassium hydroxide; In water; at 50 ℃; for 3h; Green chemistry;

DOI:10.1016/j.tet.2013.12.031

Reference yield: 98.0%

(3-methoxyphenyl)(piperidin-1-yl)methanone (69001-09-8) → 3-(1-piperidinomethyl)-anisole (107417-55-0)

Guidance literature:

With diethylzinc; lithium chloride; In tetrahydrofuran; hexane; at 20 ℃; for 24h; chemoselective reaction; Catalytic behavior; Inert atmosphere;

DOI:10.1021/ol503430t

Reference yield: 81.0%

piperidine (110-89-4) + 1-bromomethyl-3-methoxybenzene (874-98-6) → 3-(1-piperidinomethyl)-anisole (107417-55-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃; for 18h;

DOI:10.1039/c5cc00410a

upstream raw materials:

piperidine

3-methoxy-benzaldehyde

1,1'-(m-methoxybenzylidene)dipiperidine

N-Formylpiperidine

Downstream raw materials:

3-[1-piperidinylmethyl]phenol

C₁₃H₁₉NO₂Se

C₂₆H₃₆N₂O₂Se₂

C₁₃H₁₉NOSe

Refernces

• 1、 Tota, Arianna,Colella, Marco,Carlucci, Claudia,Aramini, Andrea,Clarkson, Guy,Degennaro, Leonardo,Bull, James A.,Luisi, Renzo. "N?N Bond Formation Using an Iodonitrene as an Umpolung of Ammonia: Straightforward and Chemoselective Synthesis of Hydrazinium Salts". supporting information. p. 194 - 199. Retrieved 2020/10/28.
• 2、 Kovalenko, Oleksandr O.,Volkov, Alexey,Adolfsson, Hans. "Mild and selective Et2Zn-catalyzed reduction of tertiary amides under Hydrosilylation conditions". . p. 446 - 449. Retrieved 2015/03/05.