6,8-Dichloro-3,4-dihydro-2H-benzo[b][1,4]oxazine hydrochloride

Base Information

• Chemical Name: 6,8-Dichloro-3,4-dihydro-2H-benzo[b][1,4]oxazine hydrochloride
• CAS No.: 105679-37-6
• Molecular Formula: C₈H₇Cl₂NO
• Molecular Weight: 204.056
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID30693348
• Mol file: 105679-37-6.mol

Synonyms:105679-37-6;6,8-Dichloro-3,4-dihydro-2H-benzo[b][1,4]oxazine hydrochloride;6,8-dichloro-3,4-dihydro-2H-1,4-benzoxazine;hydrochloride;6,8-Dichloro-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride;DTXSID30693348;HIZCFUQIQNNBIV-UHFFFAOYSA-N;AKOS015900799;2H-1,4-Benzoxazine,6,8-dichloro-3,4-dihydro-;6,8-Dichloro-3,4-dihydro-2H-benzo[1,4]oxazine HCl;6,8-Dichloro-3,4-dihydro-2H-benzo[b][1,4]oxazinehydrochloride;6,8-Dichloro-3,4-dihydro-2H-1,4-benzoxazine--hydrogen chloride (1/1)

Chemical Property of 6,8-Dichloro-3,4-dihydro-2H-benzo[b][1,4]oxazine hydrochloride

Chemical Property:

• PSA: 21.26000
• LogP: 3.73770
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 238.967147
• Heavy Atom Count: 13
• Complexity: 167

Purity/Quality:

98%min ^*data from raw suppliers

6,8-Dichloro-3,4-dihydro-2H-benzo[b][1,4]oxazinehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC2=C(N1)C=C(C=C2Cl)Cl.Cl

Technology Process of 6,8-Dichloro-3,4-dihydro-2H-benzo[b][1,4]oxazine hydrochloride

There total 1 articles about 6,8-Dichloro-3,4-dihydro-2H-benzo[b][1,4]oxazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-6-aminophenol (527-62-8) + ethylene dibromide (106-93-4) → C8H7Cl2NO (105679-37-6)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 85 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1021/acs.jafc.0c01867

Reference yield: 43.0%

C8H7Cl2NO (105679-37-6) + 3-(2-chlorophenyl)-5-methylisoxazole-4-carbonyl chloride (25629-50-9) → C19H13Cl3N2O3

Guidance literature:

With potassium carbonate; In toluene; at 40 ℃; for 0.416667h; Microwave irradiation;

DOI:10.1021/acs.jafc.0c01867

Reference yield: 40.0%

C8H7Cl2NO (105679-37-6) + 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride (69399-79-7) → C19H12Cl3FN2O3

Guidance literature:

With potassium carbonate; In toluene; at 40 ℃; for 0.416667h; Microwave irradiation;

DOI:10.1021/acs.jafc.0c01867

upstream raw materials:

2,4-dichloro-6-aminophenol

ethylene dibromide

Refernces