5-ACETYL-2-AMINO-4-(2-FURANYL)-6-METHYL-4H-PYRAN-3-CARBONITRILE

Base Information

• Chemical Name: 5-ACETYL-2-AMINO-4-(2-FURANYL)-6-METHYL-4H-PYRAN-3-CARBONITRILE
• CAS No.: 105263-08-9
• Molecular Formula: C13H12 N2 O3
• Molecular Weight: 244.25
• Hs Code.: 2932999099
• Mol file: 105263-08-9.mol

Synonyms:5-ACETYL-2-AMINO-4-(2-FURANYL)-6-METHYL-4H-PYRAN-3-CARBONITRILE;5-acetyl-2-amino-4-(2-furanyl)-6-methyl-4H-pyran-

Chemical Property of 5-ACETYL-2-AMINO-4-(2-FURANYL)-6-METHYL-4H-PYRAN-3-CARBONITRILE

Chemical Property:

• Vapor Pressure: 8.23E-10mmHg at 25°C
• Melting Point: 176-180 °C(lit.)
• Refractive Index: 1.584
• Boiling Point: 491.6°C at 760 mmHg
• PKA: 2.76±0.70(Predicted)
• Flash Point: 251.1°C
• PSA: 89.25000
• Density: 1.29g/cm³
• LogP: 2.65058

Purity/Quality:

98%min ^*data from raw suppliers

5-Acetyl-2-amino-4-(furan-2-yl)-6-methyl-4H-pyran-3-carbonitrile ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-ACETYL-2-AMINO-4-(2-FURANYL)-6-METHYL-4H-PYRAN-3-CARBONITRILE

There total 3 articles about 5-ACETYL-2-AMINO-4-(2-FURANYL)-6-METHYL-4H-PYRAN-3-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

furfural (98-01-1) + acetylacetone (123-54-6,81235-32-7) + malononitrile (109-77-3) → 5-acetyl-2-amino-4-furan-2-yl-6-methyl-4H-pyran-3-carbonitrile (105263-08-9)

Guidance literature:

With zinc(II) oxide; In ethanol; water; at 20 ℃; for 3.5h;

DOI:10.1016/j.tetlet.2012.06.086

Reference yield: 82.0%

2-cyano-3-(2-furanyl)acrylonitrile (3237-22-7) + acetylacetone (123-54-6,81235-32-7) → 5-acetyl-2-amino-4-furan-2-yl-6-methyl-4H-pyran-3-carbonitrile (105263-08-9)

Guidance literature:

With piperidine; In ethanol; for 4h; Product distribution; other 5-X-2-furylmethylenepropanedinitrile;

Reference yield: 70.0%

3-(furan-2-ylmethylene)pentane-2,4-dione (4728-04-5) + malononitrile (109-77-3) → 5-(5-amino-4-cyano-2-furyl)-2-cyano-2,4-pentadienenitrile (111203-08-8) + 5-acetyl-2-amino-4-furan-2-yl-6-methyl-4H-pyran-3-carbonitrile (105263-08-9)

Guidance literature:

With piperidine; In ethanol; for 4h; Product distribution; other 3-(5-X-2-furylmethylene)-2,4-pentanediones;

upstream raw materials:

3-(furan-2-ylmethylene)pentane-2,4-dione

malononitrile

2-cyano-3-(2-furanyl)acrylonitrile

acetylacetone

Downstream raw materials:

5-acetyl-3-cyano-4-(2-furyl)-6-methyl-2-(4-methylbenzylideneamino)-4H-pyran

Refernces

• 1、 Bhattacharyya, Pranabes,Pradhan, Koyel,Paul, Sanjay,Das, Asish R.. "Nano crystalline ZnO catalyzed one pot multicomponent reaction for an easy access of fully decorated 4H-pyran scaffolds and its rearrangement to 2-pyridone nucleus in aqueous media". supporting information; experimental part. p. 4687 - 4691. Retrieved 2012/09/05.
• 2、 Abdel-Latif,Shaker. "Heterocycles synthesis through reactions of nucleophiles with acrylonitriles: Part III". . p. 322 - 325. Retrieved 2007/10/02.